grant
Development of Innovative Resources to Advance MDS Research
Organization FRED HUTCHINSON CANCER CENTERLocation SEATTLE, UNITED STATESPosted 15 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AffectAntigen TargetingAntigenic DeterminantsAntigensApoptosisApoptosis PathwayArchitectureAssayBasal Transcription FactorBasal transcription factor genesBinding DeterminantsBioassayBiologicalBiological AssayBiologyBlood DiseasesBlood Precursor CellCatalogsCategoriesCell BodyCell Culture TechniquesCell LineCell ReprogrammingCell modelCellLineCellsCellular immunotherapyCellular modelCharacteristicsClinicalClinical DataClonal EvolutionClonal ExpansionClonal Hematopoietic Stem CellCommunitiesCoupledCustomDNA AlterationDNA Damage RepairDNA RepairDNA Sequence AlterationDNA mutationDataDevelopmentDiseaseDisorderDrug CombinationsDrug TherapyDrug resistanceDrugsDysmyelopoietic SyndromesEngineering / ArchitectureEngraftmentEpitopesExpression SignatureGene ExpressionGene Expression ProfileGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic AlterationGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomicsGerm LinesGoalsHematologic DiseasesHematological DiseaseHematological DisorderHematopoiesisHematopoietic Cellular Control MechanismsHematopoietic Progenitor CellsHematopoietic stem cellsHeterogeneityHigh Throughput AssayHistoryHumanImmune mediated therapyImmunologically Directed TherapyImmunotherapyImpairmentIn VitroIndividualIneffective HematopoiesisInvestigationInvestigational DrugsInvestigational New DrugsInvestigatorsLibrariesLinkMHC ReceptorMachine LearningMajor Histocompatibility Complex ReceptorMarrowMeasuresMedicationMethodologyMiceMice MammalsModelingModern ManMolecularMolecular FingerprintingMolecular ProfilingMultiomic DataMurineMusMutationMyelodysplastic DiseaseMyelodysplastic SyndromesPathogenesisPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPopulationPopulation HeterogeneityPrediction of Response to TherapyProgenitor CellsProgrammed Cell DeathProgressive DiseaseProteinsProteomeProteomicsRNA ExpressionRNA SplicingRecommendationRecording of previous eventsRecurrenceRecurrentRefractory Anemia with an Excess of BlastsRefractory anaemia with excess blastsResearchResearch PersonnelResearch ResourcesResearchersResourcesRiskSamplingSequence AlterationSmoldering LeukemiaSomatic MutationSpecific qualifier valueSpecifiedSplicingStrains Cell LinesSubgroupSurvival AnalysesSurvival AnalysisT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell receptor based immunotherapyT cell receptor cellular immunotherapyT cell receptor engineered therapyT cell receptor immunotherapyT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-Cell Antigen ReceptorsT-Cell ReceptorT-Cell Receptor TherapyT-Cell Receptor TreatmentT-Cell Receptor based TherapyT-Cell Receptor based TreatmentT-cell therapeuticsT-cell transfer therapyTCR T cell immunotherapyTCR T cell therapyTCR TherapyTCR based T cell immunotherapyTCR based TherapyTCR based immune therapyTCR based immunotherapyTCR based treatmentTCR immunotherapyTechnical ExpertiseTestingTextTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransplantationUnscheduled DNA SynthesisValidationXenograft Modeladoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapybiologicbiomarker identificationblood cell formationblood cell progenitorblood disorderblood progenitorblood stem cellblood-forming stem cellcatalogcell culturecell culturescell-based immunotherapycellular reprogrammingclone hematopoietic stem cellcohortcultured cell linecustomscytopeniadepositorydevelopmentaldiscover genesdisease modeldisorder modeldiverse populationsdriver lesiondriver mutationdrug detectiondrug interventiondrug resistantdrug sensitivitydrug testingdrug treatmentdrug/agentepigenetic regulationgene discoverygene expression patterngene expression signaturegene signaturesgenetic signaturegenome integritygenome mutationgenomic alterationgenomic integritygenotyped patientsglobal gene expressionglobal transcription profilehematopoietic differentiationhematopoietic progenitorhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellheterogeneous populationhigh throughput screeninghistorieshypoimmunityiPSiPSCiPSCsidentification of biomarkersidentification of new biomarkersimmune cell therapyimmune deficiencyimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunodeficiencyimmunogenimprovedin vivoinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinhibitorinnovateinnovationinnovativeinterdisciplinary approachleukemiamachine based learningmachine learned algorithmmachine learning algorithmmachine learning based algorithmmarker identificationmolecular profilemolecular signaturemultidisciplinary approachmultiple omic datamyelodysplasianovelon-line archiveon-line repositoryonline archiveonline repositoryoverexpressoverexpressionpathwaypatient oriented outcomespatient populationpermissivenesspharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspopulation diversityprecancerprecancerouspredict therapeutic responsepredict therapy responsepredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerpremalignantprogenitorprogenitor cell modelprogenitor modelprogramsrational designrepositoryresistance to Drugresistance to therapyresistant to Drugresistant to therapyresponserestorationscRNA sequencingscRNA-seqscreeningscreeningssingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsomatic variantstem and progenitor cell modelstem cell based modelstem cell derived modelstem cell modelstem cellssustainable resourcesustainable resourcestargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttechnical skillstherapeutic T-cell platformtherapeutic agent developmenttherapeutic developmenttherapeutic resistancetherapy predictiontherapy resistanttranscription factortranscriptional profiletranscriptional signaturetranscriptometransplanttreatment predictiontreatment resistancetreatment response predictiontreatment strategyvalidationsweb repositoryweb-based repositoryxenograft transplant modelxenotransplant model
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Myelodysplastic Syndrome (MDS) is a heterogeneous group of clonal hematopoietic stem cell diseases, resulting predominantly from acquisition of somatic mutations in hematopoietic…
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