grant
Development of High-Affinity and Selective Ligands as a Pharmacological Tool for the Dopamine D4 Receptor (D4R) Subtype Variants
Organization HIGH POINT UNIVERSITYLocation HIGH POINT, UNITED STATESPosted 1 May 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AD/HDADHDAddressAdrenergic ReceptorAdrenoceptorsAffinityAgonistAttentionAttention deficit hyperactivity disorderCell Communication and SignalingCell SignalingCognitionComputer ModelsComputerized ModelsD2 receptorD4DRDRD2 ReceptorDRD4DRD4 geneDecision MakingDevelopmentDiseaseDisorderDopamine D2 ReceptorDopamine Receptor D4Drug TherapyDrugsEpinephrine ReceptorsFDA licensed drugsFDA-approved agentsFDA-approved drugFDA-approved medicationsFDA-approved pharmaceuticalsFDA-approved therapeutic agentFood and Drug Administration approved drugFood and Drug Administration approved medicationsFood and Drug Administration approved pharmaceuticalsGenetic PolymorphismGoalsHumanIntracellular Communication and SignalingLibrariesLigandsMedicationMinisatellite RepeatsMinisatellitesModern ManMolecularPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhysiologicPhysiologicalPlayPredominantly Hyperactive-Impulsive Type Attention-Deficit DisorderPredominantly Hyperactive-Impulsive Type Hyperactivity DisorderPrevalenceReceptor ProteinReceptor SignalingResearchRoleSignal TransductionSignal Transduction SystemsSignalingSimple Repetitive SequenceSubstance Use DisorderTherapeuticVNTRVNTR LociVNTR RegionVNTR SequencesVariable Number of Tandem RepeatsVariable Tandem RepeatsVariantVariationWorkadenoreceptoranalogantagonismantagonistbiological signal transductioncomputational modelingcomputational modelscomputer based modelscomputerized modelingdesigndesigningdevelopmentaldrug interventiondrug treatmentdrug/agentin vivoneuropsychiatric diseaseneuropsychiatric disordernovelpharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspolymorphismprotein structureprotein structuresproteins structurepsychostimulant use disorderrational designreceptorreceptor functionresponsesocial rolestimulant use disordersubstance use and disordertool
Description preview
PROJECT SUMMARY/ABSTRACT
The dopamine D4 receptor (D4R) plays important roles in cognition, attention, and decision-making. The human
DRD4 gene is highly polymorphic, with different variants associated with various neuropsychiatric disorders. In
particular, VNTR variants (the three major ones are termed D4.2R, D4.4R, and D4.7R) are differentially…
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