grant
Development of functional plasticity in a simplex retina.
Organization SAN FRANCISCO STATE UNIVERSITYLocation SAN FRANCISCO, UNITED STATESPosted 1 Jul 2025Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AffectAge related macular degenerationAge-Related MaculopathyAnatomic SitesAnatomic structuresAnatomyAnimalsBasic ResearchBasic ScienceBiologic ModelsBiological ModelsBirth OrderBlindnessCell BodyCellsCessation of lifeCharacteristicsConeCone PhotoreceptorsCoupledDark AdaptationDarknessDataDeathDevelopmentDiminished VisionDiseaseDisorderElasmobranchiiElasmobranchiusElasmobranchsElectron MicroscopyElectrophysiologyElectrophysiology (science)ElectroretinographyEquilibriumExhibitsFishesGoalsHistologyHybridsIlluminationImmunofluorescenceImmunofluorescence ImmunologicImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIn Situ HybridizationKnowledgeLightLight AdaptationsLight SensitivityLightingLow VisionMacular degenerationMacular degenerative diseaseMammalian CellMediatingModel SystemMolecularNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyOrganismPartial SightPersonsPhotonsPhotophobiaPhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhysiologicPhysiologicalPhysiologyPigmentary RetinopathyPopulationPrevalenceProcessPropertyPublic HealthRNA SeqRNA sequencingRNAseqReduced VisionResearchRetinaRetinal ConeRetinal DiseasesRetinal DisorderRetinal DystrophyRetinitis PigmentosaRodRod PhotoreceptorsRods and ConesRoleScotopic AdaptationSensorySensory DeprivationShapesSightSpatial DistributionStimulusStructureSubnormal VisionSystemTapetoretinal DegenerationTestingTransmissionUnited StatesVertebrate AnimalsVertebrate PhotoreceptorsVertebratesVisionVision DisordersVisual DisorderVisual ReceptorVisual SystemVisual impairmentVisually Impaired PersonsWorkage dependent macular degenerationage induced macular degenerationage related macular diseaseage related macular dystrophybalancebalance functionblind individualblind peoplecomplement systemcone celldark reardark rearingdesigndesigningdevelopmentalelectrophysiologicalelectroretinogramexperiencefunctional adaptationfunctional plasticityfunctional restorationglobal gene expressionglobal transcription profilein situ Hybridization Geneticsin situ Hybridization Staining Methodinnovateinnovationinnovativeinsightlight intensityliving systemmodel organismneuronalnovelpatch clamppreservationpressureprogramsrare conditionrare syndromerestore functionrestore functionalityrestore lost functionrestore sightrestore visionretina diseaseretina disorderretinal neuronretinal rodsretinopathyrod and cone dystrophyrod cellrod-cone dystrophyscRNA sequencingscRNA-seqsenile macular diseasesensory inputsibling ordersight restorationsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestructural determinantsstructural factorstimelinetranscriptometranscriptome sequencingtranscriptomic sequencingtransmission processvertebratavision impairmentvision lossvision restorationvisual functionvisual informationvisual lossvisual processvisual processingvisually impaired
Description preview
PROJECT SUMMARY/ABSTRACT:
Retinal sensitivity over the full range of environmental lighting conditions, from dark to bright, is mediated by
rod and cone photoreceptors and is fundamental to vision. Importantly, when one type of photoreceptor dies,
as in retinal diseases like macular degeneration or retinal dystrophy, the remaining photoreceptor…
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