grant
Development of Cerebellar-Cortical Functional Connectivity in Youth and Its Prediction of Psychosis
Organization FEINSTEIN INSTITUTE FOR MEDICAL RESEARCHLocation MANHASSET, UNITED STATESPosted 1 Dec 2024Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY202611 year old11 years of age21 year old21 years of ageAddressAgeAmericanBenchmarkingBest Practice AnalysisBrainBrain Nervous SystemCerebellar CortexCerebellar DiseasesCerebellar DisordersCerebellar DysfunctionCerebellar SyndromesCerebellumCerebellum DiseasesCerebral cortexChildhoodClinicalClinical assessmentsCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalDataData SetDevelopmentDisturbance in cognitionDysfunctionEarly InterventionElasticityEncephalonFemaleFunctional disorderFutureGenetic RiskGoalsHumanImpaired cognitionIndividualIntervention StudiesLinkLongitudinal StudiesLongitudinal SurveysMeasuresMediatingMediationModelingModern ManNegotiatingNegotiationNeural DevelopmentOutcomeOutcome StudyPathogenesisPathologicPatientsPatternPhasePhase III studyPhenotypePhiladelphiaPhysiopathologyPredictive ValuePsychosesPsychotic DisordersResearchRestRiskSamplingSchizophreniaSchizophrenic DisordersSymptomsSystemTestingTrainingValidationWorkYouthYouth 10-21age 11age 11 yearsage 21age 21 yearsage associated effectsage effectage related effectsagesaging effectbenchmarkclinical high risk for psychosiscognitive assessmentcognitive dysfunctioncognitive functioncognitive losscognitive systemcognitive testingcohortconnectomedementia praecoxdevelopmentalearly adulthoodeleven year oldeleven years of ageemerging adultexecutive controlexecutive functionfMRI scanfunctional MRI scanfunctional magnetic resonance imaging scanhazardhigh riskimpact of ageinfluence of ageinsightintervention researchinterventional researchinterventional studyinterventions researchlarge scale datalarge scale data setslarge scale datasetslife spanlifespanlong-term studylongitudinal outcome studieslongitudinal research studymaleneuralneurodevelopmentpathophysiologypediatricphase 3 studyphenotypic datapredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerpredictive toolspreventpreventingpsychosis riskpsychoticpsychotic illnesspsychotic symptomsschizophrenicsensory systemtraittwenty-one year oldtwenty-one years of agevalidationsyouth age♀♂
Description preview
Abstract
Cerebellum dysfunction is known to be strongly implicated in the pathogenesis of psychosis. Our past research
has provided converging evidence that functional dysconnectivity in the cerebellar-cortical circuitry is a robust
neural anomaly that is ubiquitously manifest across different clinical stages and brain states in psychotic…
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