grant
Development of a Virtual Preclinical CT Platform for Advanced Imaging and Theranostics in Head and Neck Cancer Research
NIHUS FederalResearch GrantFY202514-HydroxydaunomycinAccelerationAdriamycineAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesBa elementBariumBiological FunctionBiological ProcessBlood VesselsCAT scanCT X RayCT XrayCT imagingCT scanCancer ModelCancer PatientCancer TreatmentCancerModelCancersChemotherapy and RadiationChemotherapy and/or radiationCombined Modality TherapyComplexComputational TechniqueComputed TomographyComputer ModelsComputerized ModelsContrast AgentContrast DrugsContrast MediaCustomDataDevelopmentDoxorubicinDoxorubicin LiposomeDoxorubicinaDrug DeliveryDrug Delivery SystemsDrugsEnsureEnvironmentFoundationsGeneralized GrowthGoalsGrowthHNSCCHead and Neck CancerHead and Neck CarcinomaHead and Neck NeoplasmsHead and Neck Squamous Cell CarcinomaHydroxyl DaunorubicinHydroxyldaunorubicinImageImaging ProceduresImaging TechnicsImaging TechniquesInvestigatorsIodineLiposomalLiposomal DoxorubicinLiposomal-Encapsulated DoxorubicinLiposomesMachine LearningMalignant Head and Neck NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMapsMedicationMethodologyMiceMice MammalsModelingMultimodal TherapyMultimodal TreatmentMurineMusOutcomePathologyPermeabilityPharmaceutical PreparationsPhotonsPhysiologicPhysiologicalPreclinical dataPrediction of Response to TherapyProtocolProtocols documentationRadiation therapyRadiopaque MediaRadiotherapeuticsRadiotherapyResearchResearch PersonnelResearchersResolutionRoentgen RaysSCCHNSourceStructureSurrogate MarkersTechniquesTherapeuticTherapeutic InterventionTissue GrowthTomodensitometryTranslationsTreatment EfficacyTreatment outcomeTumor ProcessTumor-Associated ProcessValidationX-RadiationX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyX-Ray RadiationX-rayXrayXray CAT scanXray Computed TomographyXray computerized tomographyangiogenesisanti-cancer researchanti-cancer therapycancer biomarkerscancer diagnosiscancer markerscancer microenvironmentcancer researchcancer therapycancer-directed therapycatscanchemo/radiation therapychemotherapychemotherapy and radiotherapyclinical applicabilityclinical applicationcombination therapycombined modality treatmentcombined treatmentcomputational modelingcomputational modelscomputational platformcomputed axial tomographycomputer based modelscomputer tomographycomputerized axial tomographycomputerized modelingcomputerized tomographycomputing platformcostcustomsdata modelingdesigndesigningdevelopmentaldigitaldigital modelsdigital twindrug/agenteffective therapyeffective treatmenthead and neck squamous carcinomahead and neck squamous cell cancerhead and neck tumorhead/neck cancerimagingimaging platformimaging studyimprovedin silicoin vivoindividualized cancer therapyinnovateinnovationinnovativeinsightintervention efficacyintervention therapymachine based learningmalignancymalignant head and neck tumorminimize animal testingminimize animal usemodel of animalmodel of datamodel the datamodeling of the datamouse modelmulti-modal therapymulti-modal treatmentmurine modelnano particlenano-sized particlenanoparticlenanosized particleneoplasm/cancernon-contrast CTnoncontrast CTnoncontrast computed tomographyontogenyopen sourceoutcome predictionpersonalization of treatmentpersonalized cancer therapypersonalized cancer treatmentpersonalized medicinepersonalized therapypersonalized treatmentphoton detectionphoton-counting detectorpre-clinicalpre-clinical studypreclinicalpreclinical findingspreclinical informationpreclinical studypredict therapeutic responsepredict therapy responseradiation effectradiation or chemotherapyradiation treatmentradiomicsreconstructionreduce animal experimentationreduce animal model usereduce animal testingreduce animal usereduce dependence on animalsreduce reliance on animalsreducing animal numbersreducing animal studiesrefractory cancerresistant cancerresolutionsresponse to therapyresponse to treatmentsimulationsingle photon detectorsurrogate bio-markerssurrogate biomarkerssynergismtheranosticstherapeutic efficacytherapeutic outcometherapeutic responsetherapy efficacytherapy optimizationtherapy outcometherapy predictiontherapy responsetimelinetomographytranslationtreatment effecttreatment optimizationtreatment predictiontreatment responsetreatment response predictiontreatment responsivenesstreatment strategytreatment with radiationtumortumor behaviortumor growthtumor microenvironmentvalidationsvascularvirtualvirtual environmentvirtual imaging
Description preview
Abstract
Effective treatment of aggressive and treatment-resistant cancers, such as head and neck squamous cell
carcinoma (HNSCC), demands innovative methodologies that accurately capture the complexities of the tumor
microenvironment and predict therapeutic responses. However, traditional imaging techniques alone may not
fully capture the complex…
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