grant
Development of a Novel Therapeutic for Mitigating Radiation-Induced Microbiome Dysbiosis and Acute Gastrointestinal Syndrome
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 1 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY202516S RNA sequencing16S RNAseq16S gene sequencing16S rDNA amplicon sequencing16S rRNA DNA sequencing16S rRNA amplicon sequencing16S rRNA gene amplicon sequencing16S rRNA gene sequencing16S rRNA genomic profiling16S rRNA sequencing16S ribosomal RNA gene sequencing16S ribosomal RNA sequencing16S seq16S sequencing16s rRNA seqAccidentsAcuteAcute Radiation SyndromeAddressAffectAlimentary CanalAmphoterinAmphoterin GeneAnimal ModelAnimal Models and Related StudiesAnimalsAntibiotic AgentsAntibiotic DrugsAntibioticsArchitectureAssayAutoregulationBacteriaBioassayBiological AssayBleedingBlood monocyteBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemC57BL/6 MouseCell BodyCell CountCell DeathCell NumberCellsCellular injuryCessation of lifeChromosomal Protein, Nonhistone, HMG1Chromosomal Protein, Nonhistone, HMG1 GeneColonDeathDevelopmentDevicesDigestive TractDoseDrugsDysfunctionEngineering / ArchitectureEpithelial CellsEpitheliumEventExposure toFDA approvedFM1 Gene ProductFunctional disorderFundingGI TractGI commensalGI microbiotaGastrointestinal InjuryGastrointestinal TractGastrointestinal microbiotaGastrointestinal tract structureGeneral RadiologyGerm-FreeGnotobioticGnotobioticsGoalsHMG-1HMG-1 GeneHMG-1 ProteinHMG1HMG1 GeneHMG3HMG3 GeneHMGB1HMGB1 ProteinHMGB1 geneHT-29HT-29 CellsHT29 CellsHematologic Body SystemHematologic Organ SystemHematopoieticHematopoietic Body SystemHematopoietic SystemHemorrhageHeparin-Binding Protein p30High Mobility Group Box Protein 1High Mobility Group Protein 1High Mobility Group Protein 1 GeneHigh-Mobility Group (Nonhistone Chromosomal) Protein 1High-Mobility Group (Nonhistone Chromosomal) Protein 1 GeneHigh-Mobility Group Box 1High-Mobility Group Box 1 GeneHomeostasisHomolog of Drosophila TOLLHourHumanImmuneImmunesIn VitroInfectionInflammationInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInflammatory ResponseInjuryIntestinalIntestinesInvadedKO miceKnock-out MiceKnockout MiceLD-50LD50LengthLethal Dose 50LigandsLipopolysaccharidesMOF syndromeMacrophageMarrow monocyteMedicationMiceMice MammalsMiscellaneous AntibioticModelingModern ManMolecularMolecular TargetMorphologyMucosaMucosal TissueMucous MembraneMucous body substanceMucusMultiple Organ Dysfunction SyndromeMultiple Organ FailureMurineMusMφNonhistone Chromosomal Protein HGM1Nonhistone Chromosomal Protein HGM1 GeneNuclearNull MouseOral AdministrationOral Drug AdministrationPathway interactionsPatternPermeabilityPharmaceutical PreparationsPhysiological HomeostasisPhysiopathologyProductionPublic HealthRadiationRadiation AccidentsRadiation DoseRadiation Dose UnitRadiation InjuriesRadiation ProtectionRadiation ToxicityRadiation exposureRadiologyRadiology SpecialtyRadioprotectionRadioprotectiveRadiotoxicityResolutionRibosomal RNA GenesRoleSBP-1SBP-1 GeneSepsisSeveritiesSignal PathwayStructureSulfoglucuronyl Carbohydrate Binding ProteinSulfoglucuronyl Carbohydrate Binding Protein GeneSurfaceSyndromeTLR proteinTLR4TLR4 geneTestingTherapeuticTimeTissuesToll HomologueToll-Like Receptor Family GeneToll-like receptorsToxic effectToxicitiesTransgenic Miceaccess restrictionsalimentary tractanimal rulebacterial communityblood lossbowelbowel inflammationcell damagecell injurycellular damagecommensal bacteria in the gastrointestinal tractcommensal bacteria in the gutcommensal bacteria in the intestinecommensal floracommensal microbescommensal microbiotacommensal microfloracytokinedamage to cellsdetermine efficacydevelopmentaldigestive canaldrug developmentdrug/agentdysbacteriosisdysbiosisdysbioticefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationenteric commensalenteric microbial communityenteric microbiotaevaluate efficacyexamine efficacyfecal microbial communityfecal microbiotagastrointestinalgastrointestinal commensalgastrointestinal microbial floragut commensalgut communitygut floragut inflammationgut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microflorahemopoieticimprovedin vivoinflamed bowelinflamed gutinflamed intestineinflammatory disease of the intestineinflammatory disorder of the intestineinjuriesinjury to cellsinjury to the intestinesintestinal autoinflammationintestinal barrierintestinal commensalintestinal epitheliumintestinal floraintestinal inflammationintestinal injuryintestinal microbiotaintestinal microfloraintestinal mucosal barrierintestinal tract microfloraintraoral drug deliveryirradiationirradiation injuryirradiation responsemass casualtymedical countermeasuremicrobial imbalancemicrobiomemicrobiome community compositionmicrobiome compositionmicrobiome species compositionmicrobiome structuremicrobiota compositionmodel of animalmonocytemouse modelmucousmultiorgan failuremultiple organ system failuremurine modelnecrocytosisnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathogenpathophysiologypathwaypreservationpublic health emergencyrRNA Genesradiation disasterradiation effectradiation eventradiation incidentradiation mitigationradiation mitigatorradiation poisoningradiation responseradio-protectionradio-protectiveradiological accidentradiological disasterradiological eventradiological incidentradiological mitigationradiological mitigatorradiomitigationradiomitigatorregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueresolutionsresponseresponse to radiationsocial rolesystemic inflammationsystemic inflammatory responsetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttimelinetissue regenerationtissue regrowthtissue renewaltissue specific regenerationtoll-like receptor 4transplant modeltreatment group
Description preview
SUMMARY
A mass casualty radiation event, such as the detonation of an improvised nuclear device or radiological dispersal
device, could lead to severe hemorrhage, multi-organ failure, and infection, potentially leading to sepsis and/or
death. The hematopoietic system and the gastrointestinal (GI) tract are among the most vulnerable tissues to…
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