grant
Development of a multifunctional interventional device for biopsy and optical imaging-based phase-0 drug response measurements
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY20262-photonAbscissionAddressAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAssayBioassayBiologicalBiological AssayBiopsyBleedingBody TissuesCathetersCauterizationCauterizeCauteryCharacteristicsClinicalClinical TrialsCommon NeoplasmCommon TumorDevelopmentDevicesDiseaseDisorderDisseminated Malignant NeoplasmDomestic RabbitDoseDrug ExposureDrug MonitoringDrug TherapyDrugsExcisionExclusionExtirpationFaceFamily suidaeFluorescenceGenesGoalsHemorrhageHistopathologyHumanImageImaging DeviceImaging InstrumentImaging ToolImmunofluorescenceImmunofluorescence ImmunologicImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImplantIn SituIndividualInduction TherapyInterventionLabelLeannessLocationMALD-MSMALDIMALDI-MSMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant Peritoneal NeoplasmMalignant Tumor of the OvaryMalignant neoplasm of ovaryMalignant neoplasm of prostateMalignant prostatic tumorMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasurementMeasuresMedicationMetastatic CancerMetastatic Malignant NeoplasmMicroscopicModelingModern ManNEOADJNeedlesNeoadjuvantNeoadjuvant TherapyNeoadjuvant TreatmentOncologistOncologyOncology CancerOperative ProceduresOperative Surgical ProceduresOpticsOryctolagus cuniculusOut-patientsOutpatientsOvarianOvary CancerPathologyPatientsPerformancePeritonealPeritoneum CancerPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhasePigsPositionPositioning AttributePre-Clinical ModelPreclinical ModelsPreparationProceduresProstateProstate CAProstate CancerProstate GlandProstate malignancyProstatic GlandRabbitsRabbits MammalsRemovalResearch ResourcesResearch SpecimenResistanceResolutionResourcesRiskSafetySelection for TreatmentsSiteSpecimenSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationSpectroscopy, Mass, Matrix-Assisted Laser Desorption-IonizationSuidaeSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSwineTM-MKRTestingThinnessTimeTissuesTranslatingTumor MarkersTumor TissueValidationWorkanalysis pipelinebiologicblood losscancer imagingclinical applicabilityclinical applicationclinical relevanceclinical translationclinically relevantclinically translatablecostdevelopmentaldrug candidatedrug developmentdrug interventiondrug treatmentdrug/agentendomicroscopyendomicrosopeexperiencefacesfacialfirst in manfirst-in-humanhigh riskimagingin vivoin vivo optical imagingindexingindividual patientinduction therapiesinsightlenslensesmatrix assisted laser desorption ionizationmicrodevicemicroendoscopemicroendoscopymicrofabricated deviceminimally invasivemodel of animalmulti-modalitymultimodalitynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoncologic imagingoncology imagingoptic imagingopticaloptical imagingoptimal therapiesoptimal treatmentsovarian cancerperitoneal cancerpersonalization of treatmentpersonalized drugspersonalized medicinepersonalized therapypersonalized treatmentpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsporcinepre-clinicalprecision drugspreclinicalpreparationspreventpreventingreal-time imagesrealtime imageresectionresistantresolutionsresponsesafety and feasibilitysecond harmonicselection of treatmentside effectspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial multiomicsspatial omicsspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatial tri-omicsspatially resolved transcriptomicsspatio transcriptomicssuccesssuidsurgerysystemic toxicitytech developmenttechnology developmenttherapy selectiontreatment selectiontumortumor biomarkertumor imagingtumor specific biomarkertwo-photonvalidations
Description preview
PROJECT SUMMARY:
Background. Traditional drug development is slow, costly, and inefficient, with over 90% of drugs failing in clinical
trials. Personalized medicine also faces challenges in accurately matching patients with optimal treatments.
"Phase-0" microdosing, involving the delivery of tiny drug doses directly into target tissues, has the…
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