grant
Development and Validation of the Down Syndrome Regression Rating Scales
Organization VIRGINIA COMMONWEALTH UNIVERSITYLocation RICHMOND, UNITED STATESPosted 20 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY202521+ years oldAccuracy of DiagnosisActivities of Daily LivingActivities of everyday lifeAcuteAddressAdolescentAdolescent YouthAdolescent and Young AdultAdultAdult HumanAffectAssessment instrumentAssessment toolBenchmarkingBest Practice AnalysisCare GiversCaregiversCatatoniaCausalityClinicClinicalCognitiveCohort StudiesCommunitiesComplexConcurrent StudiesConsensusConsumptionCountryData CollectionDelphi StudyDetectionDevelopmentDiagnosisDiagnostic testsDiseaseDisorderDown SyndromeDrugsEmotionalEnrollmentEnsureEtiologyEvaluationExhibitsFactor AnalysesFactor AnalysisFamilyFeedbackFinancial HardshipFocus GroupsFundingGenesHistoryIndividualIndividuals with down syndromeIntervention StrategiesInvestigatorsLangdon Down syndromeMeasurementMeasuresMedicalMedicationMental DepressionModelingMongolismMonitorMoodsNICHDNIMHNational Institute of Child Health and Human DevelopmentNational Institute of Mental HealthNeeds AssessmentOutcome MeasureParentsPatientsPharmaceutical PreparationsPhenotypePhysiciansPrevalencePreventative strategyPrevention strategyPreventive strategyProcessProviderPsychopathologyPublic HealthRecommendationRecording of previous eventsReportingResearchResearch PersonnelResearchersRiskSamplingSensitivity and SpecificityServicesSpecialistSpecificityStressStructureSymptomsSyndromeTestingTimeTravelTreatment outcomeTrisomy 21Validationabnormal psychologyadulthoodassociated symptombenchmarkbrain behaviorcausationchromosome 21 trisomychromosome 21 trisomy syndromeclinical careco-morbid symptomco-occuring symptomcognitive functioncognitive interviewcohortcommunity engaged approachcommunity engaged approachescommunity engaged strategiescommunity engaged strategycommunity partnered approachcommunity partnered strategycomorbid symptomconcurrent symptomcongenital acromicria syndromecooccuring symptomcostdaily living functiondaily living functionalitydepressiondevelopmentaldiagnostic accuracydiagnostic criteriadisease causationdisease riskdisorder riskdown syndrome individualsdown syndrome patientsdrug/agentenrollexecutive controlexecutive functionexperienceexternalizing behaviorfinancial adversityfinancial burdenfinancial distressfinancial insecurityfinancial strainfinancial stressfunctional abilityfunctional capacityhigh riskhistoriesimprovedindexinginsurance claimsinterestjuvenilejuvenile humanmeasurable outcomemorbus Downmotor symptomneuropsychiatricneuropsychiatrynoveloutcome measurementparentpatients with down syndromepeople with down syndromeprofound disabilitypseudohypertrophic progressive muscular dystrophyrecruitresilienceresilientresponse to therapyresponse to treatmentscreeningscreeningsserious disabilitysevere disabilityskillssymptom associationsymptom comorbiditytherapeutic responsetherapy responsetooltreatment responsetreatment responsivenesstrisomy 21 syndromevalidations
Description preview
Project Summary
Down Syndrome Regression Disorder (DSRD) is a serious neuropsychiatric syndrome that is of growing interest
among the Down syndrome (DS) community and the INCLUDE Down Syndrome Research Plan. Adolescent
and adult DSRD is associated with a subacute decline in cognitive and adaptive functioning, mood, and
catatonia, with the highest…
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