Development and validation of a Parallel Artificial Membrane Assay Permeation model for personal care formulations

Excised human skin is the most preferred approach for the assessment of topical formulations using
in vitro skin permeation studies. The major challenges in using excised human skin are (1) the
difficulty in sourcing the skin samples and (2) intra- and inter-specimen variability (Dick and
Scott, 1992; Schmook et al., 2001). Several alternative…