grant
Development and Validation of a Deep Learning system to estimate Interstitial Fibrosis from a kidney ultrasonography image
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 22 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AI systemAgeAlbuminuriaAlgorithmsAnti-Rejection TherapyArtificial IntelligenceAtrophicAtrophyBiopsyBleedingBody SizeCausalityChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClinicalClinical MarkersComputer ReasoningDataDevelopmentDiseaseDisease ProgressionDisorderEchographyEchotomographyElderlyEtiologyEvaluationFibrosisFutureGenderGoalsHemorrhageImageImmunosuppressive TherapyIndividualKidneyKidney DiseasesKidney FailureKidney InsufficiencyKidney Urinary SystemLengthMachine IntelligenceMedical UltrasoundMethodsMissionModelingMonitorNational Institutes of HealthNephropathyOutcomePathologistPatientsPerformancePersonsPlug-inPopulationPrognosisReadingRenal DiseaseRenal FailureRenal InsufficiencyRenal functionReproducibilityResearchSeveritiesSeverity of illnessSlideSystemTechniquesTestingTherapeutic immunosuppressionTimeTubularTubular formationUltrasonic ImagingUltrasonogramUltrasonographyUltrasound DiagnosisUltrasound Medical ImagingUltrasound TestUnited States National Institutes of HealthValidationWorkadvanced ageagedagesartificial immunosuppressionblindblood losscausationchronic kidney diseaseclinical biomarkersclinical practiceclinical predictorsclinical relevanceclinically relevantclinically useful biomarkerscohortdeep learningdeep learning based modeldeep learning methoddeep learning modeldeep learning strategydevelopmentaldiagnostic ultrasounddisease causationdisease severitygeriatrichazardhistopathologic examinationhistopathological examinationimagingimmunosuppression therapyimprovedinterstitialkidney biopsykidney developmentkidney disorderkidney functionkidney imagingnephrogenesisnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyprognosticprognosticationprogramsradiologistrenalrenal biopsyrenal disorderresponse to therapyresponse to treatmentroutine imagingsenior citizensonogramsonographysound measurementtherapeutic responsetherapy responsetooltreatment responsetreatment responsivenessultrasoundultrasound imagingultrasound scanninguser-friendlyvalidationsvirtual
Description preview
PROJECT SUMMARY
Interstitial fibrosis is a common finding on kidney biopsy, and strongly predicts future decline in kidney function
irrespective of the underlying etiology of kidney disease. Unfortunately, interstitial fibrosis is poorly captured by
the current clinical biomarkers of kidney function (eGFR and albuminuria). Thus, interstitial…
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