grant
Development and regulation of stem cell lineages in skin
Organization NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025ATAC sequencingATAC-seqATACseqAfferent NeuronsAssay for Transposase-Accessible Chromatin using sequencingBlood VesselsCell Communication and SignalingCell DifferentiationCell Differentiation processCell LineageCell NucleusCell SignalingCutaneous Neuroendocrine CarcinomaDevelopmentDifferentiation in cell cultureEmbryoEmbryonicEnvironmentFunctional RNAGene ExpressionGene TranscriptionGenetic TranscriptionHair FollicleHair follicle structureIn vitro cell differentiationIntervening SequencesIntracellular Communication and SignalingIntronsMaintenanceMerkel Cell TumorMerkel CellsMerkel cell cancerMerkel cell carcinomaMerkel's ReceptorMessenger RNAMiceMice MammalsModelingMurineMusNeuroendocrineNeuroendocrine Carcinoma of the SkinNeuroendocrine SystemNeurosecretory SystemsNoncoding RNANontranslated RNANuclearNucleusPhasePhysical condensationProcessProgenitor CellsProteinsRNA ExpressionRegulationSensorySensory NeuronsSignal TransductionSignal Transduction SystemsSignalingSkinTouchTouch sensationTrabecular Skin CarcinomaTranscriptTranscriptionUntranslated RNAWorkassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbiological signal transductioncell behaviorcellular behaviorcellular differentiationcondensationdevelopmentaldifferentiation in culturedifferentiation in vitroexperimentexperimental researchexperimental studyexperimentsin vitro cellular differentiationinterestintraepithelialmRNAmouse geneticsnoncodingnovelperineuralprogenitor cell poolprogenitor cell populationprogenitor poolprogenitor populationscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingstem and progenitor cell populationstem cell poolstem cell populationstem cellstactile sensationvascular
Description preview
Following up on prior work that identified the perineural microenvironment as a regulator of hair follicle stem cells, we have completed a project describing a perivascular niche for hair follicle stem cells. Moreover, we have identified that sensory touch domes in the skin, and the Merkel cells housed there are also regulated by associated Shh…
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