grant
Development and function of CD4+ memory T cells during malaria
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 15 Jun 2016Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025AddressAffectAgonistAnti-malarialsAntibody ResponseAntigen-Presenting CellsApplied GeneticsB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBiologyBloodBlood Reticuloendothelial SystemBlood erythrocyteCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCessation of lifeCharacteristicsCommunicable DiseasesContracting OpportunitiesContractsDNADataDeathDefectDeoxyribonucleic AcidDepositDepositionDevelopmentDiseaseDisorderEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessErythrocytesErythrocyticExhibitsFamilyFamily memberGeneticGlnGlutamineGoalsGroups at riskHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHemoglobinImmuneImmune mediated therapyImmune memoryImmune responseImmunesImmunityImmunologic MemoryImmunological MemoryImmunologically Directed TherapyImmunologyImmunotherapyImpairmentIndividualInducer CellsInducer T-LymphocytesInfectionInfectious DiseasesInfectious DisorderInflammasomeInflammationInnate ImmunityIntermediary MetabolismInterventionIntracellular Communication and SignalingJournalsKnowledgeL-GlutamineLinkMagazineMaintenanceMalariaMarrow erythrocyteMediatingMedicineMemoryMetabolicMetabolic ProcessesMetabolismMiceMice MammalsMolecularMolecular GeneticsMurineMusNative ImmunityNatural ImmunityNatureNon-Specific ImmunityNonspecific ImmunityPaludismParasite ControlParasitesParasitologyPathogenesisPeople at riskPersons at riskPhenotypePlasmablastPlasmodiumPlasmodium InfectionsPopulationPopulations at RiskPredispositionPublicationsQ LevoglutamideQ. LevoglutamideReagentRed Blood CellsRed CellRegulationReportingResearchResistanceResolutionScientific PublicationSeverity of illnessShapesSignal TransductionSignal Transduction SystemsSignalingSubcellular ProcessSusceptibilitySymptomsSystemT cell differentiationT cell responseT-Cell DevelopmentT-Cell OntogenyT-Cell SubsetsT-Lymphocyte DevelopmentT-Lymphocyte SubsetsT4 CellsT4 LymphocytesTestingVaccinesaccessory celladaptive immunityanamnestic reactionanti-malarial agentsanti-malarial drugsbeta-hematinbiological signal transductionblood corpusclesburden of diseaseburden of illnesscofactorcytokinedeprivationdevelopmentaldisease burdendisease severitydrinking waterepigeneticallygenetic approachgenetic strategyglobal health emergencyhaemozoinhemozoinhost responseimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunoresponseimprovedinnovateinnovationinnovativeinsightmalaria pigmentmemory CD4 T cellmemory CD4 T lymphocytenew approachesnovelnovel approachesnovel strategiesnovel strategypathogenprogramsresistantresolutionsresponsesecondary immune responsetool
Description preview
PROJECT SUMMARY
Plasmodium infections and the disease malaria remain global health emergencies. Plasmodium parasites
replicate within and cause the destruction of host red blood cells, which triggers inflammation and causes the
symptoms of malarial disease. Parasite-specific antibody responses that develop following infection are critical
for…
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