grant
Development and application of a quantitive model for HIV-1 transcriptional activation driven by TAR RNA conformational dynamics
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 17 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20253-D structure3-dimensional structure3D structureAccelerationAffinityArginineAutomobile DrivingBase SequenceBehaviorBindingBinding ProteinsBiochemicalBiochemistryBiological ChemistryBiological FunctionBiological ProcessBiophysicsCell BodyCell FunctionCell PhysiologyCell ProcessCell modelCellsCellular FunctionCellular PhysiologyCellular ProcessCellular modelCommunitiesComplexComputer ModelsComputerized ModelsDataDevelopmentDissectionElementsFeedbackFutureGene TranscriptionGenetic TranscriptionGenomeHIV-1HIV-IHIV1HumanHuman Immunodeficiency Virus Type 1Human immunodeficiency virus 1In VitroL-ArginineLibrariesLigand Binding ProteinLigand Binding Protein GeneLinkMapsMeasurementMeasuresMediatingMethodsModelingModern ManMolecularMolecular ComputationsMolecular ConfigurationMolecular ConformationMolecular Dynamics SimulationMolecular InteractionMolecular StereochemistryNon-Polyadenylated RNANucleotide SequenceProcessPropertyProtein BindingProtein ConformationProteinsPublic HealthPutative RNA-Binding RegionRNARNA Binding DomainRNA ConformationRNA DatabasesRNA ExpressionRNA Gene ProductsRNA Recognition MotifRNA SequencesRNA and protein interactionRNA-Binding ProteinsRNA-Protein InteractionRNP DomainRNP MotifRNP-1 SignatureResearchResolutionRestRibonucleic AcidRoleScienceStructureSubcellular ProcessTechnologyTestingTherapeutic InterventionThermodynamicThermodynamicsTrans-Acting FactorsTrans-ActivatorsTransactivationTransactivatorsTranscriptionTranscription ActivationTranscriptional ActivationVariantVariationViralViral Gene ProductsViral Gene ProteinsViral ProteinsVirus ReplicationWorkbiophysical characteristicsbiophysical characterizationbiophysical foundationbiophysical measurementbiophysical parametersbiophysical principlesbiophysical propertiesbiophysical sciencesbound proteincomputational modelingcomputational modelscomputer based modelscomputer based predictioncomputerized modelingconformationconformationalconformational stateconformationallyconformationscostdatabase expansiondesigndesigningdevelopmentaldrivingdriving forceexperimentexperimental researchexperimental studyexperimentsimprovedintervention therapymolecular dynamicsnucleic acid sequenceprediction algorithmpredictive modelingprotein complexprotein data bankprotein databankresolutionssmall moleculesocial rolethree dimensional structuretrans-activationviral RNAviral multiplicationviral replicationvirus RNAvirus multiplicationvirus protein
Description preview
Project Summary
Many processes essential for HIV-1 viral replication are driven by the association of regulatory RNA elements in
the retroviral genome and host/viral proteins that form biologically active complexes. Despite advances in solving
the 3D structures of RNA-protein complexes and in measuring RNA-protein interactions in vitro and in…
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