grant
Developing unique anti-EndMT nanoparticle therapy for cardiovascular disease
NIHUS FederalResearch GrantFY20262019-nCoV vaccineAPOEAccelerationAddressAffectAmericanApo-EApoE proteinApolipoprotein EBiodistributionBlood DiseasesBlood VesselsBody TissuesBone-Derived Transforming Growth FactorCOVID-19 vaccineCardiovascular DiseasesCell BodyCellsClinical ChemistryCompetitive BindingComplexDataDependenceDevelopmentDoseDose LimitingDrug KineticsDysfunctionEncapsulatedEndothelial CellsEndotheliumEngineeringEnsureEvaluationFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFormulationFoundationsFunctional disorderHDLHDL LipoproteinsHeavy LipoproteinsHematologic DiseasesHematological DiseaseHematological DisorderHigh Density LipoproteinsHistologicHistologicallyHistopathologyImage CytometryInflammatory ResponseInvestigationLifeLigandsLineage TracingLipidsLiverMediatingMesenchymalMiceMice MammalsMilk Growth FactorModelingModificationMolecular AnalysisMurineMusNCATSNational Center for Advancing Translational SciencesNon-Polyadenylated RNAPalsyParalysedParticle SizePatientsPharmacokineticsPhasePhysiopathologyPlatelet Transforming Growth FactorPlayPlegiaProcessProductionPulmonary HypertensionQuality ControlRNARNA Gene ProductsRNA based therapeuticsRNA based therapyRNA deliveryRNA targeting drugRNA targeting therapeuticsRNA therapyRNA-targeting therapyReproducibilityRibonucleic AcidRoleSARS-CoV-2 vaccineSARS-coronavirus-2 vaccineSafetySevere Acute Respiratory Syndrome CoV 2 vaccineSevere acute respiratory syndrome coronavirus 2 vaccineSignal PathwaySpecificityStandardizationSystemTGF BTGF-betaTGF-βTGFbetaTGFβTechnologyTherapeuticTherapeutic EffectTissuesToxic effectToxicitiesTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTreatment EfficacyValidationVascular DiseasesVascular DisorderVascular Endotheliumalpha-Lipoproteinsanalytical methodblood disorderblood vessel disordercardiovascular disease therapycardiovascular disordercardiovascular disorder therapycell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingclinical developmentclinical translationclinically translatablecohortcompetitively boundcoronavirus disease 2019 vaccinecoronavirus disease-19 vaccinedesigndesign validationdesign verificationdesigningdevelopmentalendothelial dysfunctionflow cytophotometryhealth care burdenhemodynamicshepatic body systemhepatic organ systemhypoxia-induced pulmonary hypertensionhypoxic pulmonary hypertensionindexinginnovateinnovationinnovativeintervention efficacylipid based nanoparticlelipid nanoparticlemanufacturemanufacturing processnCoV vaccinenCoV-19 vaccinenCoV19 vaccinenano particle deliverynanoparticle deliverednanoparticle deliverynanoparticle therapynovelparalysisparalyticparticlepathophysiologypulmonaryquantumresponsesafety assessmentsexsocial rolesuccesstechnology platformtechnology systemtherapeutic RNAtherapeutic efficacytherapeutic nanoparticlestherapeutic outcometherapeutic targettherapy efficacytherapy outcomeuptakevaccine against 2019-nCovvaccine against COVID-19vaccine against SARS-CoV-2vaccine against SARS-coronavirus-2vaccine against Severe Acute Respiratory Syndrome CoV 2vaccine against Severe acute respiratory syndrome coronavirus 2vaccine candidates against SARS-CoV-2vaccine for novel coronavirusvaccines preventing COVIDvaccines to prevent COVIDvalidation studiesvalidationsvascularvascular bedvascular dysfunctionvasculopathyzeta potential
Description preview
PROJECT SUMMARY Vascular diseases driven by endothelial dysfunction represent a major therapeutic
challenge due to the lack of cell-specific delivery systems. While TGFβ-driven endothelial-to-mesenchymal
transition (EndMT) has emerged as a key therapeutic target, current approaches are limited by off-target
effects of systemic TGFβ inhibition. We…
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