grant
Developing ultrasound contrast agents and signal processing for structural and functional imaging in type 1 diabetes
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 1 Jun 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AcousticsArchitectureB9 endocrine pancreasBeta CellBindingBiodistributionBlood Vessel ImagingBlood VesselsBlood flowBrittle Diabetes MellitusCD62L AntigensCell BodyCell Communication and SignalingCell SignalingCell surfaceCellsChronicClinicClinicalComplement ActivationComplications of Diabetes MellitusContrast AgentContrast DrugsContrast MediaDetectionDevelopmentDiabetes ComplicationsDiabetes MellitusDiabetes-Related ComplicationsDiabetic ComplicationsDiagnosisDiameterDiseaseDisease ProgressionDisorderDropsEchographyEchotomographyEndocrine PancreasEndothelial CellsEngineering / ArchitectureExtravasationFunctional ImagingGasesGoalsHistologicHistologicallyHumulin RHypoglycemiaIDDMImageImaging ProceduresImaging TechnicsImaging TechniquesImmune infiltratesImmune mediated therapyImmune systemImmunologically Directed TherapyImmunotherapyImpairmentIn VitroIndividualInfiltrationInflammationInsulinInsulin CellInsulin Secreting CellInsulin-Dependent Diabetes MellitusIntracellular Communication and SignalingInvestigationIonizing Electromagnetic RadiationIonizing radiationIslands of LangerhansIslets of LangerhansJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusL-SelectinLAM-1LAM-1 Leukocyte Adhesion MoleculeLECAM-1LeakageLeu-8 AntigenLigandsLymphocyte Adhesion Molecule 1MapsMeasurementMedical UltrasoundMel-14 AntigenMicrobubblesMicroscopyMicrovascular PermeabilityMolecular InteractionMolecular TargetMonitorNesidioblastsNovolin ROutcomePancreasPancreaticPancreatic IsletsPars endocrina pancreatisPatientsPeptidesPerfusionPhasePhysiologic ImagingPre-Clinical ModelPreclinical ModelsPreventative treatmentPreventive treatmentRadiationRadiation-Ionizing TotalRadiopaque MediaRegular InsulinResolutionRiskRouteSensitivity and SpecificitySignal TransductionSignal Transduction SystemsSignalingSpecificitySpillageSudden-Onset Diabetes MellitusSurfaceT1 DMT1 diabetesT1DT1DMTQ1 AntigenTechniquesTherapeutic InterventionType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusUltrasonic ImagingUltrasonogramUltrasonographyUltrasound DiagnosisUltrasound Medical ImagingUltrasound TestVisualizationbiological signal transductionblood glucose regulationclinical imagingcomplement pathway regulationcontrast enhancedcontrast imagingdevelopmentaldiabetesdiagnostic ultrasoundglucose controlglucose homeostasisglucose regulationhuman subjecthypoglycemichypoglycemic episodesimage-based methodimagingimaging approachimaging based approachimaging methodimaging modalityimmune cell infiltrateimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimprovedin vivoin vivo Modelinflammation markerinflammatory markerinnovateinnovationinnovativeinsulin dependent diabetesinsulin dependent diabetes mellitus onsetinsulin dependent type 1insulitisintervention therapyionizing outputisletjuvenile diabetesjuvenile diabetes mellitusketosis prone diabetesmetermouse modelmurine modelnanonovelpancreas imagingphysiological imagingpreventpreventingresolutionsresponsesignal processingsonogramsonographysound measurementstructural imagingsuccesssuper high resolutionsuperresolutiontype 1 diabetes onsettype I diabetestype one diabetesultra high resolutionultrasoundultrasound imagingultrasound scanningvaporizationvascularvascular imagingvasculature Imagingβ-cellβ-cellsβCell
Description preview
PROJECT SUMMARY
Type 1 diabetes (T1D) results from the destruction of insulin producing β-cells upon immune infiltration and
inflammation of the islets of Langerhans in the pancreas. Prior to T1D onset there is an asymptomatic phase
of many years which presents a window for therapeutic intervention. However, there are limited means for
detecting…
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