grant
Developing robust and scalable genomics tools and databases to analyze immune receptor repertoires across broad populations
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 10 Feb 2023Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2025Adaptive Immune SystemAlgorithmsAllelesAllelomorphsAssayAutoimmune DiseasesB blood cellsB cellB cell receptorB cellsB-Cell Antigen ReceptorB-CellsB-LymphocytesB-cellBenchmarkingBest Practice AnalysisBioassayBioinformaticsBiological AssayCancersCatalogingCertificationCollectionCommunicable DiseasesCommunitiesDNA amplificationDataData BasesData ScienceData SetData SystemsDatabasesDecrease health disparitiesDegenerative Neurologic DisordersEthnic GroupEthnic PeopleEthnic PopulationEthnic individualEthnicity PeopleEthnicity PopulationEuropeanEuropean ancestryGenesGeneticHealth disparity mitigationHealth disparity reductionHeterogeneityHigh-Throughput Nucleotide SequencingHigh-Throughput SequencingHumanIT SystemsImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune systemImmunesImmunogeneticsImmunogenomicsImmunologic DiseasesImmunologic ReceptorsImmunological DiseasesImmunological DysfunctionImmunological ReceptorsImmunological System DysfunctionIndividualInfectious DiseasesInfectious DisorderInformation DisseminationInformation SystemsInformation Technology SystemsInternationalLower health disparitiesMalignant NeoplasmsMalignant TumorMedicalMethodsMitigate health disparitiesModern ManNGS MethodNGS systemNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNon-Polyadenylated RNAPopulationPopulation HeterogeneityRNARNA Gene ProductsRNA SeqRNA sequencingRNAseqReceptor ProteinReduce health disparitiesRibonucleic AcidSamplingT cell receptor repertoire sequencingT cell receptor sequencingT-CellsT-LymphocyteT-cell receptor repertoireTCR repertoireTCR repertoire sequencingTCR sequencingTCR-seqTCRseqTechnologyVariantVariationacquired immune systemadaptive immune responseaggregation databaseautoimmune conditionautoimmune disorderautoimmunity diseasebenchmarkbio-informatics toolbioinformatics toolcost effectivedata basedeep sequencingdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdisparity in healthdissemination of resultsdiverse populationsethnic diversityethnic subgroupethnically diverseethnicity groupgenetic architecturegenomic toolshealth disparityheterogeneous populationhuman diseaseimmune healthimmune receptorimmune system healthimprovedinsightmalignancyneoplasm/cancerneurodegenerative illnessnext gen sequencingnext generation sequencingnextgen sequencingnovelpopulation diversityreceptorthymus derived lymphocytetooltranscriptome sequencingtranscriptomic sequencing
Description preview
Abstract
The recent advances in high-throughput sequencing technologies enable cost-effective characterization of the immune system and provide novel opportunities to study adaptive immune receptor repertoire (AIRR) at the population scale. In particular, AIRR analysis provides essential insight into the complexity of the immune system across a…
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