grant
Developing Immunogens to Elicit Broadly Neutralizing anti-HIV-1 Antibodies
Organization CALIFORNIA INSTITUTE OF TECHNOLOGYLocation PASADENA, UNITED STATESPosted 10 Feb 2013Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY20267S Gamma GlobulinAIDS VaccinesAIDS vaccineAbbreviationsAffinityAffinity ChromatographyAnimalsAntibodiesAntigensAssayB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBindingBioassayBiochemicalBiological AssayBlood SerumCell BodyCellsCellular AssayClinical Treatment MoabCollaborationsComplexCross ReactionsCustomData AnalysesData AnalysisDomestic RabbitE coliE. coliELISAEndotoxinsEnv trimerEnvelope ProteinEnzyme-Linked Immunosorbent AssayEscherichia coliEvaluationExperimental ModelsFreedomGerm LinesGlycansHIV EnvHIV Envelope Glycoprotein gp120HIV Envelope Protein gp120HIV env Protein gp120HIV envelopeHIV envelope proteinHIV glycoprotein EnvHIV vaccineHIV-1HIV-1 EnvHIV-1 envelopeHIV-1 glycoprotein EnvHIV-IHIV/AIDS VaccinesHIV1HTLV-III gp120Human Immunodeficiency Virus Type 1Human Immunodeficiency Virus-1Human ResourcesHuman immunodeficiency virus 1Ig Somatic HypermutationIgGImmunizationImmunizeImmunoglobulin GImmunoglobulin Somatic HypermutationIn VitroInvestigatorsKineticsLibertyLibrariesLightLiquid substanceM mulattaM. mulattaMacaca mulattaMacaca rhesusMammalian CellManpowerMeasuresMembraneMethodologyMethodsMiceMice MammalsMolecular InteractionMolecular Sieve ChromatographyMonitorMonoclonal AntibodiesMurineMusOryctolagus cuniculusPhotoradiationPolysaccharidesPostdocPostdoctoral FellowProceduresProductionPropertyProteinsProtocolProtocols documentationRabbitsRabbits MammalsRecombinant ProteinsRecoveryRegimenResearch AssistantResearch AssociateResearch PersonnelResearchersRhesus MacaqueRhesus MonkeyRobotSHIVSOSIPSchemeSerumSize Exclusion ChromatographyStudentsSurfaceSurface Plasmon ResonanceSystemTestingTimeTrainingVaccinatedVaccinationYeastsaffinity purificationassay developmentcell assaycloud basedcross reactivitycustomsdata accessdata interpretationdata managementdesigndesigningdiscover vaccinesenv Antigensenv Gene Productsenv Glycoproteinsenv Polyproteinsenv Proteinenzyme linked immunoassayexperimentexperimental researchexperimental studyexperimentsfluidgp120gp120 ENV Glycoproteingp120(HIV)gp160human immunodeficiency virus vaccineimmunogeninstrumentliquidmAbsmembrane structuremonoclonal Absnano particlenano-sized particlenanomaterialsnanoparticlenanosized particleneutralizing antibodypersonnelpost-docpost-doctoralpost-doctoral traineeprotein expressionreceptor bindingreceptor boundresearch associatesscreeningscreeningssimian HIVsimian human immunodeficiency virussomatic hypermutationvaccination studyvaccination trialvaccine against HIVvaccine discoveryvaccine studyvaccine trial
Description preview
Project Summary: Protein Expression and Automated Assays Core
Biochemical, structural, and immunization experiments to evaluate new prime/boost regimens
designed and selected to induce broadly neutralizing antibodies (bNAbs) will require expression
and purification of large numbers of proteins, including HIV-1 envelope proteins and Abs. The…
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