grant
Developing Immunogens to Elicit Broadly Neutralizing anti-HIV-1 Antibodies
Organization CALIFORNIA INSTITUTE OF TECHNOLOGYLocation PASADENA, UNITED STATESPosted 10 Feb 2013Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026AIDSAIDS vaccine developmentAbbreviationsAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immunodeficiency SyndromeAdoptive TransferAdvanced HIVAffectAffinityAnimal ExperimentsAntibodiesAntibody RepertoireAntibody ResponseAntigenic DeterminantsAntigensB blood cellsB cellB cellsB-Cell DevelopmentB-CellsB-LymphocytesB-cellBindingBinding DeterminantsBinding SitesCell BodyCellsClinical Treatment MoabCombining SiteComplementarity Determining RegionsComplimentarity Determining RegionDataDevelopmentDiseaseDisorderEpitopesEvolutionFeedbackFrequenciesGenesGerm LinesGerminal CenterGoalsHIV InfectionsHIV vaccine developmentHIV viral infectionHIV virus infectionHIV-1HIV-1 infectionHIV-1 vaccineHIV-1 vaccine developmentHIV-IHIV1HIV1 vaccineHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHistocompatibility ComplexHistocompatibility ComplicesHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency Virus-1Human immunodeficiency virus 1Hypervariable LoopHypervariable RegionsIGHIGH@ gene clusterIg Somatic HypermutationIgH locusImmune responseImmune systemImmunizationImmunochemical ImmunologicImmunoglobulin Heavy Chain GenesImmunoglobulin Heavy GeneImmunoglobulin Heavy LocusImmunoglobulin Hypervariable RegionImmunoglobulin Somatic HypermutationImmunologicImmunologicalImmunologicallyImmunologicsInducer CellsInducer T-LymphocytesInfection by HIV-1Infection from HIV-1Infection of HIV-1Intervention StrategiesKI miceKnock-inKnock-in MouseKnowledgeLaboratoriesMHC ReceptorMajor Histocompatibility ComplexMajor Histocompatibility Complex ReceptorMajor Histocompatibility ComplicesMasksMembraneMemory B CellMemory B-LymphocyteMiceMice MammalsModelingModern ManMolecular InteractionMonoclonal AntibodiesMurineMusOutcomePeptide-MHCPeptide-Major Histocompatibility Protein ComplexPeptide/MHC ComplexPeptidesPersonsPhysiologicPhysiologicalPublishingReactionReactive SiteRecombinantsRegimenReportingReproducibilitySevere HIV DiseaseSpecificityStructure of germinal center of lymph nodeT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteT-cell receptor repertoireTCR repertoireTestingTimeTransgenic MiceV3 LoopV3 Loop of HIV-1VaccinesWild Type Mouseanimal experimentbasebasesbiochemical toolsbiochemistry toolsdesigndesigningdevelop AIDS vaccinedevelop HIV vaccinedevelop HIV-1 vaccinedevelop a HIV vaccinedevelop a HIV-1 vaccinedevelopment of a HIV vaccinedevelopmentalexperimentexperimental animalexperimental animalsexperimental researchexperimental studyexperimentsgenetic elementhost responsehuman immunodeficiency virus infectionimmune system responseimmunization strategyimmunogenimmunoglobulin heavy chain locusimmunoresponseimprovedin vivoinfected with HIVinfected with human immunodeficiency virusknockinknockin micemAbsmembrane structuremonoclonal Absmouse modelmurine modelmutantneutralizing antibodynovelpMHCpolyclonal antibodyrecruitresponsesomatic hypermutationthymus derived lymphocytevaccination strategyvaccine against HIV-1wildtype mouse
Description preview
Project Summary
Despite AIDS being a preventable disease, UNAIDS reports millions of newly HIV-1 infected people every
year. An efficacious vaccine for HIV-1 is therefore highly sought after. Despite many efforts, attempts to create
immunization regimens that reproducibly elicit broadly neutralizing antibodies (bNAbs) against HIV-1 have
failed…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click