grant
Developing Immunogens to Elicit Broadly Neutralizing anti-HIV-1 Antibodies
Organization CALIFORNIA INSTITUTE OF TECHNOLOGYLocation PASADENA, UNITED STATESPosted 10 Feb 2013Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026AIDS VirusAbbreviationsAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAffinityAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesAntibody AffinityAntibody ResponseAntigenic DeterminantsAntigensApicalAutologousAutomobile DrivingB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBindingBinding DeterminantsBinding SitesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCell LineageClinicalClinical Treatment MoabCollaborationsCombining SiteDNA mutationDevelopmentDoseEnv trimerEnvelope ProteinEpitope MappingEpitopesEventFeedbackFrequenciesGenerationsGenetic ChangeGenetic defectGenetic mutationGerm LinesGlycansHIVHIV EnvHIV envelopeHIV envelope proteinHIV glycoprotein EnvHIV-1HIV-1 EnvHIV-1 envelopeHIV-1 glycoprotein EnvHIV-IHIV1HumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency Virus-1Human Immunodeficiency VirusesHuman immunodeficiency virus 1ImmunizationImmunogeneticsInfectionLAV-HTLV-IIILaboratoriesLineage TracingLymphadenopathy-Associated VirusM mulattaM. mulattaMacaca mulattaMacaca rhesusMapsMembraneMessenger RNAModelingModern ManMolecularMolecular InteractionMonkeysMonoclonal AntibodiesMutationPathway interactionsPatternPeptidesPolysaccharidesProcessProteinsReactive SiteRectumRegimenRhesusRhesus MacaqueRhesus MonkeySHIVSOSIPSpecificityT4 CellsT4 LymphocytesTestingTranslatingVaccinatedVaccinationVaccinesVariantVariationViralVirus-HIVWorkantigen antibody affinitycell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingchallenge in rhesus macaquesdesigndesigningdevelopmentaldrivingenv Antigensenv Gene Productsenv Glycoproteinsenv Polyproteinsenv Proteingenome mutationimmunogenimmunogenicityimprovedinfected rhesus macaquesinfected rhesus monkeyinfection in rhesus macaquesinfection of rhesus macaqueslipid based nanoparticlelipid nanoparticlemAbsmRNAmRNA lipid nano particle vaccinemRNA-LNP based vaccinemRNA-LNP combination vaccinesmRNA-LNP vaccinesmembrane structuremodel of animalmonoclonal Absnano particlenano-sized particlenanoparticlenanosized particleneutralizing antibodynovelpathwaypre-clinical trialpreclinical trialprotective efficacyresponserhesus challengerhesus macaque challengerhesus monkey infectionsimian HIVsimian human immunodeficiency virussuccessvector
Description preview
PROJECT SUMMARY
SHIV-infected rhesus macaques (RMs) develop HIV-1 broadly neutralizing antibodies (bNAbs) via Env-antibody
(Ab) co-evolutionary pathways that recapitulate events in HIV-1 infected humans. This includes the frequency of
bNAb induction, the viral epitopes targeted, and the immunogenetic and structural features of bNAbs, which are
all…
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