grant
Developing Immunogens to Elicit Broadly Neutralizing anti-HIV-1 Antibodies
Organization CALIFORNIA INSTITUTE OF TECHNOLOGYLocation PASADENA, UNITED STATESPosted 10 Feb 2013Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY20267S Gamma GlobulinAb responseAbbreviationsAffectAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesAntibody FormationAntibody ProductionAntigenic DeterminantsAntigensAssayBindingBinding DeterminantsBinding SitesBioassayBiological AssayBlood SerumClinical Treatment MoabCollaborationsCombining SiteDNA mutationDataDevelopmentELISAEngineeringEnv trimerEnzyme-Linked Immunosorbent AssayEpitope MappingEpitopesEvolutionGenetic ChangeGenetic defectGenetic mutationGerm LinesGerminal CenterGlycansHIV EnvHIV Envelope Glycoprotein gp120HIV Envelope Protein gp120HIV InfectionsHIV env Protein gp120HIV envelopeHIV envelope proteinHIV glycoprotein EnvHIV viral infectionHIV virus infectionHIV-1HIV-1 EnvHIV-1 envelopeHIV-1 glycoprotein EnvHIV-1 infectionHIV-1 vaccineHIV-IHIV1HIV1 vaccineHTLV-III gp120Human Immunodeficiency Virus Type 1Human Immunodeficiency Virus-1Human immunodeficiency virus 1IgGImmunizationImmunizeImmunoglobulin GImpairmentIn VitroInfectionInfection by HIV-1Infection from HIV-1Infection of HIV-1Infection preventionM mulattaM. mulattaMacaca mulattaMacaca rhesusMapsMemory B CellMemory B-LymphocyteMolecular InteractionMolecular Sieve ChromatographyMonoclonal AntibodiesMutationPolysaccharidesPreparationPrevent infectionProteinsReactive SiteRegimenRhesus MacaqueRhesus MonkeySHIVSOSIPSerumShapesSize Exclusion ChromatographyStructure of germinal center of lymph nodeSurface Plasmon ResonanceTransgenic MiceVaccinationVaccinesViralWild Type MouseWorkantibody biosynthesischallenge in rhesus macaquesdesigndesigningdevelopmentalenzyme linked immunoassayexperimentexperimental researchexperimental studyexperimentsgenome mutationgp120gp120 ENV Glycoproteingp120(HIV)human immunodeficiency virus infectionimmunogenimmunoglobulin biosynthesisimprovedin vivoinfected rhesus macaquesinfected rhesus monkeyinfected with HIVinfected with human immunodeficiency virusinfection in rhesus macaquesinfection of rhesus macaquesmAbsmodel of animalmonoclonal Absnano particlenano-sized particlenanoparticlenanosized particleneutralizing antibodyparticlepreparationspressurepreventpreventingprotein expressionrecruitresponserhesus challengerhesus macaque challengerhesus monkey infectionscaffoldscaffoldingsimian HIVsimian human immunodeficiency virusvaccine against HIV-1vaccine candidatewildtype mouse
Description preview
Project Summary/Abstract: Project 1
An effective HIV-1 vaccine likely requires induction of Abs against HIV-1 Env that neutralize across the majority
of circulating viral strains (i.e., broadly neutralizing antibodies; bNAbs). Because administered bNAbs are
protective against HIV-1 infection in animal models, it is widely believed that a vaccine…
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