grant
Developing Immunogens to Elicit Broadly Neutralizing anti-HIV-1 Antibodies
Organization CALIFORNIA INSTITUTE OF TECHNOLOGYLocation PASADENA, UNITED STATESPosted 10 Feb 2013Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2025AIDSAbbreviationsAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immunodeficiency SyndromeAdoptive TransferAffectAffinityAnimal ExperimentsAntibodiesAntibody RepertoireAntibody ResponseAntigenic DeterminantsAntigensB blood cellsB cellB cellsB-Cell DevelopmentB-CellsB-LymphocytesB-cellBindingBinding DeterminantsBinding SitesCell BodyCellsClinical Treatment MoabCombining SiteComplementarity Determining RegionsComplimentarity Determining RegionDataDevelopmentDiseaseDisorderEpitopesEvolutionFeedbackFrequenciesGenesGerm LinesGerminal CenterGoalsHIV vaccineHIV-1HIV-1 vaccineHIV-IHIV/AIDS VaccinesHIV1HIV1 vaccineHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHistocompatibility ComplexHistocompatibility ComplicesHumanHuman Immunodeficiency Virus Type 1Human immunodeficiency virus 1Hypervariable LoopHypervariable RegionsIGHIGH@ gene clusterIg Somatic HypermutationIgH locusImmune responseImmune systemImmunizationImmunochemical ImmunologicImmunoglobulin Heavy Chain GenesImmunoglobulin Heavy GeneImmunoglobulin Heavy LocusImmunoglobulin Hypervariable RegionImmunoglobulin Somatic HypermutationImmunologicImmunologicalImmunologicallyImmunologicsInducer CellsInducer T-LymphocytesInfectionIntervention StrategiesKI miceKnock-inKnock-in MouseKnowledgeLaboratoriesMHC ReceptorMajor Histocompatibility ComplexMajor Histocompatibility Complex ReceptorMajor Histocompatibility ComplicesMasksMembraneMemory B CellMemory B-LymphocyteMiceMice MammalsModelingModern ManMolecular InteractionMonoclonal AntibodiesMurineMusOutcomePeptide-MHCPeptide-Major Histocompatibility Protein ComplexPeptide/MHC ComplexPeptidesPersonsPhysiologicPhysiologicalPublishingReactionReactive SiteRecombinantsRegimenReportingReproducibilitySpecificityStructure of germinal center of lymph nodeT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteT-cell receptor repertoireTCR repertoireTestingTimeTransgenic MiceV3 LoopV3 Loop of HIV-1VaccinesWild Type Mouseanimal experimentbasebasesbiochemical toolsbiochemistry toolsdesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentalexperimentexperimental animalexperimental animalsexperimental researchexperimental studyexperimentsgenetic elementhost responsehuman immunodeficiency virus vaccineimmune system responseimmunization strategyimmunogenimmunoglobulin heavy chain locusimmunoresponseimprovedin vivoknockinknockin micemAbsmembrane structuremonoclonal Absmouse modelmurine modelmutantneutralizing antibodynovelpMHCpolyclonal antibodyrecruitresponsesomatic hypermutationthymus derived lymphocytevaccination strategyvaccine developmentwildtype mouse
Description preview
Project Summary
Despite AIDS being a preventable disease, UNAIDS reports millions of newly HIV-1 infected people every
year. An efficacious vaccine for HIV-1 is therefore highly sought after. Despite many efforts, attempts to create
immunization regimens that reproducibly elicit broadly neutralizing antibodies (bNAbs) against HIV-1 have
failed…
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