grant
Developing Immunogens to Elicit Broadly Neutralizing anti-HIV-1 Antibodies
Organization CALIFORNIA INSTITUTE OF TECHNOLOGYLocation PASADENA, UNITED STATESPosted 10 Feb 2013Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2025AIDSAIDS/HIVAb responseAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immunodeficiency SyndromeAffectAffinityAnimal ModelAnimal Models and Related StudiesAnimalsAnti-Retroviral AgentsAntibodiesAntibody FormationAntibody ProductionAntibody ResponseAntigenic DeterminantsAntigensAntiseraAssayAttenuatedB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBinding DeterminantsBinding SitesBioassayBioinformaticsBiological AssayClinical Treatment MoabCollaborationsCombining SiteDNA mutationDataDevelopmentDomestic RabbitDrugsELISAElectron MicroscopyEngineeringEnzyme-Linked Immunosorbent AssayEpitope MappingEpitopesEventEvolutionFailureFeedbackFundingGenetic ChangeGenetic defectGenetic mutationGerm LinesGerminal CenterGlycansGoalsHIV vaccineHIV-1HIV-1 vaccineHIV-IHIV/AIDSHIV/AIDS VaccinesHIV1HIV1 vaccineHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHumanHuman Immunodeficiency Virus Type 1Human immunodeficiency virus 1Immune SeraImmunizationImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImpairmentInducer CellsInducer T-LymphocytesLaboratoriesLeftM mulattaM. mulattaMacaca mulattaMacaca rhesusMedicationMembraneMemory B CellMemory B-LymphocyteMessenger RNAMiceMice MammalsModelingModern ManMolecularMonoclonal AntibodiesMurineMusMutationOryctolagus cuniculusOutcomePathway interactionsPersonsPharmaceutical PreparationsPhylogenetic AnalysisPhylogeneticsPolysaccharidesPrimatesPrimates MammalsProteinsPublic HealthPublicationsRNA vaccineRNA-based vaccineRabbitsRabbits MammalsReactive SiteRegimenResearchRhesus MacaqueRhesus MonkeySHIVScientific Advances and AccomplishmentsScientific PublicationStructure of germinal center of lymph nodeTestingTransgenic MiceVaccinationVaccine DesignVaccine ResearchVaccinesViralVirusanti-retroviralantibody biosynthesisattenuateattenuatesbiophysical analysisbiophysical studiesbooster dosebooster shotbooster vaccinechallenge in rhesus macaquesdesigndesigningdevelopmentaldrug/agentenzyme linked immunoassayexperimentexperimental researchexperimental studyexperimentsgenome mutationhuman immunodeficiency virus vaccineimmune serumimmunogenimmunogenicityimmunoglobulin biosynthesisimprovedinfected rhesus macaquesinfected rhesus monkeyinfection in rhesus macaquesinfection of rhesus macaquesmAbsmRNAmRNA lipid nano particle vaccinemRNA vaccinemRNA-LNP based vaccinemRNA-LNP combination vaccinesmRNA-LNP vaccinesmRNA-based vaccinemembrane structuremodel of animalmonoclonal Absnano particlenano-sized particlenanoparticlenanosized particleneutralizing antibodynext generationnovelpathwaypressurepreventpreventingprotection pathwayprotective pathwayprotein expressionrecruitresponserhesus challengerhesus macaque challengerhesus monkey infectionscaffoldscaffoldingscientific accomplishmentsscientific advancesscreeningscreeningssimian HIVsimian human immunodeficiency virussynergismtoolvaccine boostvaccine platformvaccine-related research
Description preview
PROJECT SUMMARY
A central goal in HIV/AIDS vaccine research is the elicitation of broadly neutralizing antibodies (bNAbs). During
the previous funding period, the Bjorkman lab used novel design strategies to develop HIV-1 envelope (Env)
trimer-based immunogens to elicit bNAbs against single and multiple epitopes, including the V3 glycan patch,
CD4…
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