grant
Developing Immunogens to Elicit Broadly Neutralizing anti-HIV-1 Antibodies
Organization CALIFORNIA INSTITUTE OF TECHNOLOGYLocation PASADENA, UNITED STATESPosted 10 Feb 2013Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY20257S Gamma GlobulinAIDS VirusAb responseAbbreviationsAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAffectAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesAntibody FormationAntibody ProductionAntigenic DeterminantsAntigensAssayBindingBinding DeterminantsBinding SitesBioassayBiological AssayBlood SerumClinical Treatment MoabCollaborationsCombining SiteDNA mutationDataDevelopmentELISAEngineeringEnzyme-Linked Immunosorbent AssayEpitope MappingEpitopesEvolutionGenetic ChangeGenetic defectGenetic mutationGerm LinesGerminal CenterGlycansHIVHIV Envelope Glycoprotein gp120HIV Envelope Protein gp120HIV env Protein gp120HIV envelopeHIV envelope proteinHIV-1HIV-1 vaccineHIV-IHIV1HIV1 vaccineHTLV-III gp120Human Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman immunodeficiency virus 1IgGImmunizationImmunizeImmunoglobulin GImpairmentIn VitroInfectionInfection preventionLAV-HTLV-IIILymphadenopathy-Associated VirusM mulattaM. mulattaMacaca mulattaMacaca rhesusMapsMemory B CellMemory B-LymphocyteMolecular InteractionMolecular Sieve ChromatographyMonoclonal AntibodiesMutationPolysaccharidesPreparationPrevent infectionProteinsReactive SiteRegimenRhesus MacaqueRhesus MonkeySHIVSerumShapesSize Exclusion ChromatographyStructure of germinal center of lymph nodeSurface Plasmon ResonanceTransgenic MiceVaccinationVaccinesViralVirus-HIVWild Type MouseWorkantibody biosynthesischallenge in rhesus macaquesdesigndesigningdevelopmentalenzyme linked immunoassayexperimentexperimental researchexperimental studyexperimentsgenome mutationgp120gp120 ENV Glycoproteingp120(HIV)immunogenimmunoglobulin biosynthesisimprovedin vivoinfected rhesus macaquesinfected rhesus monkeyinfection in rhesus macaquesinfection of rhesus macaquesmAbsmodel of animalmonoclonal Absnano particlenano-sized particlenanoparticlenanosized particleneutralizing antibodyparticlepreparationspressurepreventpreventingprotein expressionrecruitresponserhesus challengerhesus macaque challengerhesus monkey infectionscaffoldscaffoldingsimian HIVsimian human immunodeficiency virusvaccine candidatewildtype mouse
Description preview
Project Summary/Abstract: Project 1
An effective HIV-1 vaccine likely requires induction of Abs against HIV-1 Env that neutralize across the majority
of circulating viral strains (i.e., broadly neutralizing antibodies; bNAbs). Because administered bNAbs are
protective against HIV-1 infection in animal models, it is widely believed that a vaccine…
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