grant
Developing functional and authenticated RPE tissue from iPS cells
Organization NATIONAL EYE INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAnimal ModelAnimal Models and Related StudiesAntibodiesAphidicolinApicalBiotechBiotechnologyBody TissuesCell BodyCell CycleCell Division CycleCell ShapeCell TherapyCell TransplantationCellsCiliaClassificationCollaborationsDegenerative DisorderDevelopmentDrugsDyneinDynein ATPaseDynein Adenosine TriphosphataseDynein AdenosinetriphosphataseEffectivenessElectrophysiologyElectrophysiology (science)EpitheliumEye diseasesGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGoalsHigh Throughput AssayIn VitroLabelMediatingMediatorMedicationMethodsMiceMice MammalsMorphologyMurineMusNeurophysiology / ElectrophysiologyOuter pigmented layer of retinaPathway interactionsPatientsPeripheralPharmaceutical PreparationsPhenotypePhotoreceptor CellPhotoreceptorsPhotosensitive CellPigment cell layer of retinaPigmented layer of retinaPopulationProcessProtein TraffickingRetinal Pigment EpitheliumRetinal pigment epithelial cellsStructure of retinal pigment epitheliumSystematicsTestingTherapeuticTissuesTranscript Expression AnalysesTranscript Expression AnalysisVisual ReceptorWNT Signaling PathwayWNT signalingWorkadulthoodanalyze gene expressioncell based interventioncell mediated interventioncell mediated therapiescell typecell-based therapeuticcell-based therapycellular therapeuticcellular therapycellular transplantciliogenesisciliopathycilium biogenesisdegenerative conditiondegenerative diseasedevelopmentaldisease modeldisorder modeldrug/agentelectrophysiologicaleye disordergene expression analysisgene expression assayhiPSChigh throughput screeninghuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsiPSiPSCiPSCsimprovedinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinhibitorinsightmachine learned algorithmmachine learning algorithmmachine learning based algorithmmaculamacularmodel of animalmonolayermouse modelmurine modelocular diseaseocular disorderophthalmopathypathwaypharmacologicpostnatalpre-clinicalpreclinicalpreventpreventingprotein transportregeneration based therapyregeneration therapyregenerative therapeuticsregenerative therapytraffickingtranscriptional profiling
Description preview
Human iPSC-derived retinal pigment epithelium (RPE) cells do not fully mature in vitro and often continue to express certain markers. This limits their use as accurate disease models for adult-onset conditions and reduces their effectiveness as cell therapy candidates for degenerative eye diseases. To overcome this, we developed methods to fully…
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