grant
Developing closed-loop tonic motor activation therapy for treatment of refractory restless legs syndrome
Organization NOCTRIX HEALTH, INCLocation Pleasanton, UNITED STATESPosted 1 May 2020Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY202521+ years oldAddressAdultAdult HumanAffectAlgorithmsBrainBrain Nervous SystemCell Communication and SignalingCell SignalingCenters for Disease ControlCenters for Disease Control and PreventionCenters for Disease Control and Prevention (U.S.)ClinicalClinical TrialsCodeCoding SystemCross-Over DesignsCrossover DesignDataDetectionDevicesDopamine AgonistsDopamine Receptor AgonistsDopaminergic AgonistsDoseDrugsEkbom SyndromeEncephalonEpidemicEsthesiaFDA approvedFeedbackGenerationsGrantHealthHomeHyperactivityIRBIRBsInstitutional Review BoardsIntracellular Communication and SignalingLabelLeadLegLegal patentLifeMeasuresMedicare claimMedicationMemoryMorbidityMorbidity - disease rateMotorMovementNerve FibersOpiatesOpioidOutcomePatentsPatient RecruitmentsPatientsPb elementPerformancePeripheral Nerve StimulationPharmaceutical PreparationsPhasePolysomnographyPopulationPrevalenceProcessProgramming LanguagesProtocolProtocols documentationPublic HealthPythonsQOLQuality of lifeRandomizedRecommendationRefractoryReportingRestless LegsRestless Legs SyndromeRiskSBIRSensationSensorySignal TransductionSignal Transduction SystemsSignalingSleepSleep DeprivationSleep DisordersSleep FragmentationsSleep MonitoringSmall Business Innovation ResearchSmall Business Innovation Research GrantSomnographySpecificityStructureSymptomsSystemTechnologyTimeTrainingTranslatingUnited StatesUnited States Centers for Disease ControlUnited States Centers for Disease Control and PreventionValidationWorkactigraphactigraphyadulthoodautomated therapyautomated treatmentautomatic treatmentbattery lifebiological signal transductionbody movementclinical significanceclinical validationclinically significantcommercializationcontrol theorydeficient sleepdesigndesigningdiariesdosagedrug/agentfall asleepheavy metal Pbheavy metal leadhomesimprovedinadequate sleepinnovateinnovationinnovativeinsufficient sleepnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapyoff-label applicationoff-label drugoff-label medicationoff-label prescribingoff-label useparticipant recruitmentpatient populationprimary end pointprimary endpointrandomisationrandomizationrandomly assignedrecruitsecondary end pointsecondary endpointside effectsleep amountsleep debtsleep deficiencysleep deficitsleep diseasessleep durationsleep dysfunctionsleep episodesleep illnesssleep insufficiencysleep intervalsleep lengthsleep losssleep measurementsleep onsetsleep periodsleep polysomnographysleep problemsleep quantitysleep timesuccesstherapeutically effectivetime asleeptime during sleeptime in sleeptime spent asleeptime spent sleepingtraditional therapyvalidations
Description preview
Summary: Restless Legs Syndrome (RLS) is a prevalent and debilitating sleep disorder that affects a significant
portion of the adult population, leading to considerable sleep deprivation and a reduction in quality of life. Current
treatments for RLS provide mixed results and, in the case of medications, undesirable side effects. The need for…
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