grant
Developing and Discovering Covalent Inhibitors through Fragmentation-First Experimentation
Organization ST. JUDE CHILDREN'S RESEARCH HOSPITALLocation MEMPHIS, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025Antimicrobial ResistanceBacteriaBar CodesBiologicalBiologyCancersCharacteristicsChemicalsCommunicable DiseasesContracting OpportunitiesContractsDataData CollectionDiseaseDisorderInfectious DiseasesInfectious DisorderInvestigationMalignant NeoplasmsMalignant TumorMedicineMethodsMolecularOutputPatternPlayProcessProteinsProtocolProtocols documentationReactionReagentResearchResearch ActivityResistanceRibosomesRoleStructureSystemTimeaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsaging populationanti-microbial resistantbarcodebiologicbiomacromolecularbiomacromoleculechemical reactionchemical synthesiscombatdesigndesigningempowermentinhibitorinnovateinnovationinnovativemalignancymolecular scaleneoplasm/cancernovelopportunity costparallelizationpopulation agingprecision medicineprecision-based medicineprogramsrational designresistance to anti-microbialresistantresistant to antimicrobialsmall moleculesocial roletimelinetool
Description preview
Abstract
Iterative chemical innovation plays an essential role in the study and treatment of disease. In an aging
population and with antimicrobial resistance on the rise we could not be more dependent on state-of-the-art
medicines to battle cancer and infectious disease. However, despite nearly two centuries of important progress
in chemical…
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