grant
Developing and democratizing technologies to study 3D genome organization
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 1 Aug 2020Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAdoptionAffinity ChromatographyBiochemicalBiologyCancersCell BodyCell FunctionCell NucleusCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessChromatinChromosomal OrganizationChromosomal StructureChromosome MappingChromosome OrganizationChromosome StructuresChromosomesDNADNA Damage RepairDNA RepairDNA ReplicationDNA SequenceDNA SynthesisDNA biosynthesisData SetDeoxyribonucleic AcidDevelopmentDiameterDiseaseDisorderFISH TechnicFISH TechniqueFISH analysisFISH assayFluorescence In Situ HybridizationFluorescent in Situ HybridizationGene Action RegulationGene ExpressionGene Expression RegulationGene LocalizationGene MappingGene Mapping GeneticsGene RegulationGene Regulation ProcessGene TranscriptionGenetic TranscriptionGenomeGenome StabilityGenomic StabilityGenomicsHealthHumanIndividualLabelLinkage MappingMalignant NeoplasmsMalignant TumorMethodsModern ManMolecularMotivationNon-Polyadenylated RNANucleusOrganellesPatternPlayPositionPositioning AttributeProcessProteinsRNARNA ExpressionRNA Gene ProductsRepetitive ElementRepetitive RegionsRepetitive SequenceResearchRibonucleic AcidRoleSiteSpeedStructureSubcellular ProcessTechnologyTotal Human and Non-Human Gene MappingTranscriptionUnscheduled DNA SynthesisWorkaffinity purificationdevelopmentaldevelopmental diseasedevelopmental disordergene locusgenetic locusgenetic mappinggenomic locationgenomic locushuman diseaseinsightmalignancymeterneoplasm/cancernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachprogramsrepairrepairedscreeningscreeningssocial rolethree dimensional
Description preview
PROJECT SUMMARY
Each human nucleus contains two meters of DNA that is packaged into an organelle a mere ~10 µm diameter.
Despite this dramatic difference in scale, the three-dimensional organization of the genome is non-random
and plays a critical functional role in health and disease. My research group is focused on the building robust
and…
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