grant

Developing a SMART scaffold for bladder augmentation

Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 1 Jan 2025Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026AccelerationAcute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyAddressAdoptionAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAreaAthymic RatsAutologousBaboonsBiocompatible MaterialsBiologic CharacteristicBiologicalBiological CharacteristicsBiomaterialsBladderBladder TissueBladder Urinary SystemBlood Precursor CellBlood VesselsBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemCD34CD34 geneCell BodyCell Communication and SignalingCell SignalingCellsCitratesClinicalClinical ResearchClinical StudyCollagenCommon Rat StrainsDataDiseaseDisorderElastomersElectric ConductivityElectrical ConductivityElectronicsEngineeringEventExtravasationFailureFunctional RegenerationGoalsGrowth AgentsGrowth FactorGrowth SubstancesHPCA1Hematopoietic Progenitor CellsHematopoietic stem cellsHeptylcarbinolsHeterogeneityHumanHydroxyoctanesImmunocompetentInfectionInflammatoryInterstitial CystitisIntestinalIntestinesIntracellular Communication and SignalingKidney FailureKidney InsufficiencyLeakageMalignantMalignant - descriptorMalignant Urinary Tract NeoplasmMechanicsMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMethodsModelingModern ManMonitorMuscleMuscle TissueNatural regenerationNude RatsOctanolsOctyl AlcoholsOctylic AlcoholsOperative ProceduresOperative Surgical ProceduresOrganOutcomePapioPathologicPatient CarePatient Care DeliveryPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPerforationPerformancePhylogenetic AnalysisPhylogeneticsPhysiologicPhysiologicalPolyglycolic AcidPolyglycolidePolymersPredispositionProcessProteins Growth FactorsRatRats MammalsRattusRegenerationRegenerative engineeringRenal FailureRenal InsufficiencyReportingSafetySchistorrhachisSerious Adverse EventSevere Adverse EventSignal TransductionSignal Transduction SystemsSignalingSmall Intestinal SubmucosaSpillageSpina BifidaSpinal DysraphiaSpinal DysraphismSurfaceSurgicalSurgical InterventionsSurgical ProcedureSusceptibilitySystemTechnologyThickThicknessTimeTissuesTraumaUnited StatesUrinary Tract CancerUrinationUrineUrologic CancerUrological CancerUrotheliumacute kidney injurybiocompatibilitybioelectronicsbiologicbiological materialbiological signal transductionbiomaterial compatibilitybladder pain syndromeblood cell progenitorblood progenitorblood stem cellblood-forming stem cellbowelcare for patientscare of patientscaring for patientscleft spineclinical relevanceclinical translationclinically relevantclinically translatablecontinuous monitoringdensityelastomericelectrical conductanceelectronicelectronic deviceexperienceexperimentexperimental researchexperimental studyexperimentshematopoietic progenitorhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellhydrocele spinalisimmune competentimplantationimprovedmechanicmechanicalmechanical propertiesmesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmicturitionmodel of animalmuscularoutcome predictionpainful bladder syndromepatient oriented outcomesperipheral nerve regenerationpolymerpolymericpre-clinicalpreclinicalrachischisis posteriorreal time monitoringrealtime monitoringregenerateregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueregeneration functionregenerativeregenerative functionregenerative functionalityscaffoldscaffoldingserious adverse experienceserious adverse reactionstandard of caresurgerytissue regenerationtissue regrowthtissue renewaltissue specific regenerationtooltranslation strategytranslational approachtranslational strategyurinary bladdervascularwirelesswireless monitorwireless sensor
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Description preview

SUMMARY
Each year in the United States there are 14,000 bladder augmentation enterocystoplasty surgeries to address

trauma, urological cancers, severe cases of spina bifida, and interstitial cystitis. Although enterocystoplasty is

the standard of care for patients with end-stage pathologic bladder, 33% of patients have complications due to…

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Developing a SMART scaffold for bladder augmentation — NORTHWESTERN UNIVERSITY | UNITED STATES | Jan 2025 | Dev Procure