grant
Developing a Novel Causal Discovery Framework to Unveil Individualized Cell-Cell Communication Networks
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 1 Mar 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2025AgingAlgorithmic SoftwareAlgorithmic ToolsAlgorithmsAutoregulationBayesian ModelingBayesian NetworkBayesian adaptive designsBayesian adaptive modelsBayesian belief networkBayesian belief updating modelBayesian frameworkBayesian hierarchical modelBayesian network modelBayesian nonparametric modelsBayesian spatial data modelBayesian spatial image modelsBayesian spatial modelsBayesian statistical modelsBayesian tracking algorithmsBiologicalBiological MarkersBiopsyBody TissuesCancerousCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell modelCell to Cell Communication and SignalingCell-Cell SignalingCell-to-Cell InteractionCellsCellular modelCommunicationComplexComputational toolkitComputer Software ToolsConvolution KernelDataData SetDevelopmentDiffusionDiseaseDisorderEmbryoEmbryonicEnvironmentGene ExpressionGenesGenomicsGoalsHeterogeneityHomeostasisIndividualInterpretable MLInterpretable machine learningIntracellular Communication and SignalingInvestigationInvestigatorsKnowledgeLeadLearningLigandsLung InflammationMediatingModelingMolecularMolecular FingerprintingMolecular ProfilingOlder PopulationPatientsPatternPb elementPhysiologicPhysiologicalPhysiological HomeostasisPneumonitisPopulationProcessPulmonary InflammationRNA SeqRNA sequencingRNAseqReceptor ProteinReceptor SignalingResearch PersonnelResearchersResolutionSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSoftware AlgorithmSoftware ToolsTechniquesTestingTissue SampleTissuesTransmissionVariantVariationbio-markersbiologicbiologic markerbiological signal transductionbiomarkercomparing females and malescomparing women and mencomputational frameworkcomputational toolboxcomputational toolscomputational toolsetcomputer frameworkcomputerized toolscustomized therapycustomized treatmentdeep learningdeep learning methoddeep learning strategydevelopmentaldiffuseddiffusesdiffusingdiffusionsdrug discoveryempowermentexplainable MLexplainable machine learningfemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesglobal gene expressionglobal transcription profileheavy metal Pbheavy metal leadindividual heterogeneityindividual variabilityindividual variationindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentintercellular communicationinterestmachine learning based modelmachine learning modelmolecular drug targetmolecular pharmacotherapy targetmolecular profilemolecular signaturenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyolder groupsolder individualsolder personpatient specific therapiespatient specific treatmentpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentprecision medicineprecision-based medicineprogramsreceptorresolutionssoftware toolkitspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicstailored medical treatmenttailored therapytailored treatmenttranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicstransmission processtumorunique treatmentweb sitewebsitewomen compared to menwomen compared with menwomen versus menwomen vs. men
Description preview
Project Summary/Abstract
The overall goal of this study is to develop a computational framework integrating deep learning and causal
discovery algorithms to unveil the individualized (or instance-specific) cell-cell communication networks
(CCCNs) underlying tissue environment heterogeneity of individual tissue samples. The versatility of this…
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