grant
Developing a Nanopore Tweezer Toolkit for Analyzing Kinase Structural Dynamics and Screening Allosteric Inhibitors
Organization UNIVERSITY OF MASSACHUSETTS AMHERSTLocation HADLEY, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY20253-D structure3-dimensional structure3D structureATP-protein phosphotransferaseActive SitesAllosteric RegulationAssayBindingBioassayBiological AssayBiophysicsCancersCatalysisCell Communication and SignalingCell SignalingCryo-electron MicroscopyCryoelectron MicroscopyCytolysinsDNA mutationDNA seqDNA sequencingDNAseqDataDetectionDiseaseDisease ResistanceDisorderDown-RegulationDrug DesignDrug InteractionsDrug ScreeningDrug TargetingDrug resistanceDrugsDysfunctionEPH- and ELK-Related Tyrosine KinaseEPH-and ELK-Related KinaseElectron CryomicroscopyEngineeringEnzymatic BiochemistryEnzymologyEphrin Type-A Receptor 8Ephrin Type-A Receptor 8 PrecursorFDA approvedFaceFamilyFunctional disorderGenetic ChangeGenetic defectGenetic mutationHigh Throughput AssayIntracellular Communication and SignalingKinase Family GeneKinasesKineticsLabelLeadLibrariesLigand BindingLigandsLinkMalignant NeoplasmsMalignant TumorMapsMeasurementMedicationMethodologyMethodsMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMolecular StereochemistryMonitorMotionMovementMutationNaturePathway interactionsPb elementPeptidesPharmaceutical PreparationsPhosphotransferase GenePhosphotransferasesPhysiopathologyPropertyProtein AnalysisProtein EngineeringProtein KinaseProtein Tyrosine KinaseProtein Tyrosine Kinase EEKProteinsReactionResistanceResolutionRoentgen RaysRoleScienceScreening for cancerSignal TransductionSignal Transduction SystemsSignalingSubstrate InteractionTechniquesTechnologyTherapeuticThermodynamicThermodynamicsTimeTransphosphorylasesTyrosine KinaseTyrosine Kinase DomainTyrosine-Protein Kinase Receptor EEKTyrosine-Specific Protein KinaseTyrosylprotein KinaseVariantVariationWorkX-RadiationX-Ray RadiationX-rayXrayanomerbiological signal transductionbiophysical foundationbiophysical modelbiophysical principlesbiophysical sciencesbody movementconformationconformationalconformational stateconformationallyconformationscontinuous monitoringcryo-EMcryoEMcryogenic electron microscopycryptographydisease diagnosticdrug discoverydrug resistantdrug/agentearly cancer detectionenzyme activityexperiencefacesfacialgenetic protein engineeringgenome mutationglycogen synthase a kinaseheavy metal Pbheavy metal leadhigh throughput screeninghigh-throughput drug screeninghydroxyalkyl protein kinasehydroxyaryl protein kinaseimprovedineffective therapiesineffective treatmentinhibitorinnovateinnovationinnovativeinsightmalignancymaltose-binding proteinmolecular modelingmutantnano porenanoporeneoplasm/cancernew approachesnew technologynovelnovel approachesnovel strategiesnovel strategynovel technologiespathophysiologypathwayphosphorylase b kinase kinaseprecision medicineprecision-based medicineprotein designprotein structureprotein structuresproteins structureresistance mechanismresistance to Drugresistance to diseaseresistantresistant diseaseresistant mechanismresistant to Drugresistant to diseaseresolutionsscreeningscreening cancer patientsscreeningssensorsingle moleculesocial rolesuccesssugartargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttech developmenttechnology developmenttherapeutic targetthree dimensional structuretooltyrosyl protein kinase
Description preview
PROJECT ABSTRACT
Protein nanopores are powerful sensors that enable a new class of single-molecule
measurements, with applications ranging from fundamental science to commercial DNA
sequencing. Our focus is on developing and applying novel nanopore approaches to tackle
challenges in protein analysis, ultimately improving disease diagnostics and…
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