grant
Developing 3D patient-specific iPS cell derived RPE/choroid models
Organization NATIONAL EYE INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressAdventitial CellAge related macular degenerationAge-Related MaculopathyAnatomic SitesAnatomic structuresAnatomyAtrophic AMDAtrophic age-related macular degenerationBackBlindnessBlood VesselsBlood-Retinal BarrierBody TissuesCell BodyCell DifferentiationCell Differentiation processCellsChoroidCollagenComplexDevelopmentDiseaseDisease PathwayDisorderDorsumDrugsDry AMDDrynessElderlyEncapsulatedEndothelial CellsEngineeringEventEyeEyeballFibroblastsFollow-Up StudiesFollowup StudiesGelGoalsLeannessMacrophageMedicationModelingMφNon-exudative age-related macular degenerationNonexudative age-related macular degenerationOuter pigmented layer of retinaPathologicPathologyPatientsPericapillary CellPericytesPerivascular CellPharmaceutical PreparationsPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhysiologicPhysiologicalPigment cell layer of retinaPigmented layer of retinaProliferatingPropertyRegulationRetinal DegenerationRetinal Pigment EpitheliumRetinal pigment epithelial cellsRoleRouget CellsSideStructure of retinal pigment epitheliumSystemTechnologyTestingThinnessTissue EngineeringTissuesVEGFVEGFsVascular Endothelial Growth FactorsVisual Receptoradvanced ageage dependent macular degenerationage induced macular degenerationage related macular diseaseage related macular dystrophybio-printingbiodegradable scaffoldbioengineered tissuebioprintingcellular differentiationdegenerative retina diseasesdevelopmentaldrug/agentdry age-related macular degenerationengineered tissuegeriatrichuman modeliPSiPSCiPSCsin vitro Modelinduced pluripotent cellinduced pluripotent stem cellinduced pluripotent stem cells derived from patientsinduced pluripotent stem cells from patientsinducible pluripotent cellinducible pluripotent stem cellmodel of humanmonolayerpatient derived human iPSpatient derived human iPSCpatient derived human induced pluripotent stem cellpatient derived iPSpatient derived iPSCpatient derived induced pluripotent cellspatient derived induced pluripotent stem cellspatient-derived pluripotent stem cellsphotoreceptor degenerationretina degenerationretinal degenerativeretinal degenerative diseasessenile macular diseasesenior citizensocial rolestemtherapeutic candidatethree dimensionalvascularvision lossvisual loss
Description preview
Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly and progresses to two advanced stages: dry and wet AMD. The dry form is triggered by the loss of retinal pigment epithelium (RPE) cells, followed by photoreceptor (PR) degeneration and thinning of the choroid. In contrast, the wet form is characterized by…
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