grant
Determining the Role of Brain-Derived CCN3 in Bone and Marrow Fat Metabolism
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 15 Jul 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025Adipose tissueAdult-Onset Diabetes MellitusAffectAgingAppearanceArcuate NucleusAssayBioassayBiological AssayBone DensityBone FormationBone InjuryBone MarrowBone Marrow Reticuloendothelial SystemBone Mineral DensityBrainBrain Nervous SystemCaliforniaCausalityClinicalClinical TrialsCommunicationCoupledDeteriorationDevelopmentDevelopment PlansDiabetes MellitusDoseEncephalonEndocrine Gland SecretionEndocrinologyEstrogen ReceptorsEtiologyExposure toFatsFatty TissueFatty acid glycerol estersFellowshipFemaleFemurFinancial HardshipFractureFutureGeneticGoalsGrantHealthHigh Fat DietHollyHormonesHumanHypothalamic structureHypothalamusIn VitroInfundibular NucleusIntermediary MetabolismKISS1KISS1 Metastasis SuppressorKISS1 geneKetosis-Resistant Diabetes MellitusKiSS-1LactationLearningLength of LifeLinkLongevityMGC39258MarrowMaturity-Onset Diabetes MellitusMeasuresMedialMediatingMedicineMenopauseMentorsMentorshipMetabolicMetabolic ProcessesMetabolismMetabolism and EndocrinologyMetastinMiceMice MammalsModelingModern ManMothersMurineMusNIDDKNIDDMNational Institute of Diabetes and Digestive and Kidney DiseasesNerveNerve CellsNerve UnitNeural CellNeurocyteNeuronsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusObesityOperative ProceduresOperative Surgical ProceduresOsteocytesOsteogenesisOsteoporosisOsteoporotic riskOutcomePatientsPerimenopausalPerimenopausePhenotypePhysiciansPhysiologicPhysiologicalPhysiologyPlayPost-MenopausePost-menopausal PeriodPostmenopausal PeriodPostmenopauseRegulationResearchRoleSan FranciscoScientistSkeletal boneSkeletonSlow-Onset Diabetes MellitusStable Diabetes MellitusStructure of nucleus infundibularis hypothalamiSurgicalSurgical InterventionsSurgical ProcedureSwitzerlandT2 DMT2DT2DMTestingTherapeutic HormoneTrainingTranscriptType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUniversitiesWomanWorkWritingadiposeadiposityadult onset diabetesafter menopauseage associated diseaseage associated disorderage associated impairmentage dependent diseaseage dependent disorderage dependent impairmentage related human diseaseage-related diseaseage-related disorderage-related impairmentagedaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsaging populationbonebone fracturebone fragilitybone lossbone massbone qualitybone tissue formationcareercareer developmentcausationcorpulencedevelopmentaldiabetesdietarydisease causationdisease modeldisorder modelfat metabolismfinancial adversityfinancial burdenfinancial distressfinancial insecurityfinancial strainfinancial stressfollowing menopausefracture riskhypothalamicimprovedin vivoin vivo Modelketosis resistant diabeteskisspeptinknock-downknockdownlactatinglactationallater in lifelater lifelipid metabolismmalematurity onset diabetesmenopause transitionmutantnano-molarnanomolarneuronalnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetoffspringosteogenicosteoporosis riskovariectomy-induced bone lossovariectomy-induced osteoporosisoverexpressoverexpressionpast menopauseperi-menopausalperi-menopausepopulation agingpost-menopausalpostmenopausalpostmenopausal statusprofessorprogenitor biologyprogenitor cell biologyprogenitor cell nicheprogenitor nicheprogramsresponserisk developing osteoporosisrisk factor for osteoporosisshRNAshort hairpin RNAskeletalskeletal diseaseskeletal disorderskeletal progenitorskeletal progenitor cellskeletal stem cellskeletonsskillssmall hairpin RNAsocial rolestem and progenitor biologystem and progenitor cell nichestem cell biologystem cell nichesurgerytherapeutic targettransition to menopausetransitional menopausetype 2 DMtype II DMtype two diabeteswhite adipose tissueyellow adipose tissue♀♂
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ABSTRACT/PROJECT SUMMARY
This application presents a five-year mentored research and training plan that will prepare Dr. Muriel Babey to
be a leader in the field of the skeletal, aging, and metabolic physiology. Dr. Babey completed her MD at the
University of Berne, Switzerland and her clinical fellowship of Endocrinology, Metabolism and Diabetes…
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