grant
Determining the function of Trp-positive trigeminal sensory neurons innervating the submandibular salivary glands
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 17 Jul 2024Deadline 16 Jul 2028
NIHUS FederalResearch GrantFY2025AcidityAcuteAddressAffectAfferent NeuronsAlveolodental LigamentAlveolodental MembraneAmericanAsialiaAutoimmune DiseasesBase CompositionBody TissuesBrainBrain Nervous SystemBrain StemBrainstemBuccal CavityBuccal Cavity Head and NeckC10Cavitas OrisCell NucleusChemical StimulationChemicalsClassificationCre driverCuesDREADDsDataDetectionDiagnosticDigestionDuctDuct (organ) structureDysfunctionEncephalonFeedbackFoundationsFunctional disorderGasser's GanglionGasserian GanglionGenesGeneticGlandGoalsH+ elementHeadHydrogen IonsHyposalivationImageImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIn Situ HybridizationIn vivo two-photon calcium imagingInfection preventionLabelLacrimal GlandsLacrimal gland structureLinkLiquid substanceMajor Salivary GlandMajor salivary gland structureMammaliaMammalsMediatingMethodsMiceMice MammalsMolecularMouse StrainsMouthMouth DrynessMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuronsNucleusOralOral cavityOral healthOsmolar ConcentrationOsmolarityOutputPainPainfulParasympathetic Nervous SystemParotidParotid GlandPatientsPeriodontal LigamentPeriodontal MembranePeripheralPhysiologicPhysiologicalPhysiopathologyPlayPrevent infectionProduce salivaProteinsProtonsQOLQuality of lifeReceptor ProteinReflexReflex actionRegulationReporterResearchRoleSalivaSaliva productionSalivarySalivary GlandsSalivary excretionSalivary hypofunctionSalivationSemilunar GanglionSensorySensory NeuronsSicca SyndromeSingle cell seqSjogren's DiseaseSjogren's SyndromeSjogrensSjögren SyndromeStaining methodStainsStructureStructure of trigeminal ganglionSublingual GlandSublingual Salivary GlandSubmandibular glandSubmaxillary GlandSympathetic Nervous SystemSystemSystematicsTRP channelTemperatureTimeTissuesTooth DemineralizationTooth HypomineralizationTouchTouch sensationTransient receptor potential channelTransmissionTrigeminal GangliasTrigeminal GanglionTrigeminal SystemViral VectorViscosityXerostomiaXerostomicaptyalismautoimmune conditionautoimmune disorderautoimmunity diseasecalcium indicatorcellular targetingcomparativecompare to controlcomparison controlcraniofacial tissuedental healthdesigner receptors exclusively activated by designer drugsdry mouthexperimentexperimental researchexperimental studyexperimentsfallsfluidimagingin situ Hybridization Geneticsin situ Hybridization Staining Methodin vivo calcium imaginginnervationirradiationliquidmolecular targeted therapeuticsmolecular targeted therapiesmolecular targeted treatmentnerve supplyneural cell bodyneuronalneuronal cell bodynew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoral drynessoral tissuepathophysiologyreceptorresponsesaliva compositionsaliva samplesaliva secretionsalivary gland hypofunctionsalivary productionsalivary samplesalivary secretionsensory feedbackside effectsingle cell next generation sequencingsingle cell sequencingsocial rolesomasomatosensorytactile sensationtherapeutic targettranscriptomicstransmission processtrigeminalxerodermosteosis
Description preview
ABSTRACT
Dry mouth affects nearly 30% of Americans, yet there are no treatments that effectively regulate saliva
production and composition long-term. Autonomic neurons innervating the major salivary glands have been
well-characterized and represent a main therapeutic target to trigger saliva production. However, this approach
only offers acute…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click