grant
Determining role of 14-3-3zeta in IL-17A signaling
Organization UNIVERSITY OF KENTUCKYLocation LEXINGTON, UNITED STATESPosted 10 Jun 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025Adaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAffectAnimal ModelAnimal Models and Related StudiesAnimalsAtrophic ArthritisAttenuatedAutoimmune DiseasesBindingBiologyBody TissuesCTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCXCL1CXCL1 geneCell Communication and SignalingCell SignalingChaperoneChronicCommon Rat StrainsCommunicable DiseasesComplementary DNAComplexCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneDataDiseaseDisorderExhibitsExtracellular Signal-Regulated Kinase GeneFLJ11330FibroblastsGRO1GROAGene ExpressionGene TranscriptionGene TransferGenesGenetic TranscriptionGoalsIL-17IL-17 GeneIL-17AIL-17A GeneIL-17EIL17IL17 ProteinIL17 geneIL17AIL17A GeneImmuneImmunesImmunologyImpairmentIn VitroInfectious DiseasesInfectious DisorderInflammatoryInflammatory ArthritisInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin ActivationInterleukin-17InterleukinsIntracellular Communication and SignalingInvestigationJointsKO miceKnock-out MiceKnockout MiceKnowledgeLinkMAP Kinase GeneMAPKMGSAMapsMediatingMiceMice MammalsMitogen-Activated Protein Kinase GeneModelingMolecularMolecular ChaperonesMolecular InteractionMurineMusNF-Kb-Activating Kinase GeneNull MouseOPGLOutcomePathogenesisPathogenicityPhenotypePhosphorylationPhysiologicPhysiologicalPlayPopulationPredispositionPreventionProtein BiochemistryProtein PhosphorylationProtein/Amino Acid BiochemistryProteinsPublicationsPublishingRANKLRNA ExpressionRatRats MammalsRattusReceptor ProteinReceptor SignalingRegulationResearchRheumatoid ArthritisRoleSCYB1Scientific PublicationSignal TransductionSignal Transduction SystemsSignalingSpecificitySusceptibilitySynovitisT2KTBK1TBK1 geneTNF Receptor-Associated Factor 6 GeneTNF Receptor-Associated FactorsTNF receptor-associated factor 5TNFSF11TNFSF11 geneTRAF ProteinsTRAF2TRAF2 geneTRAF5TRAF6TRAF6 geneTRAP3TestingTherapeuticTissuesTranscriptionTumor Necrosis Factor Receptor Associated FactorsUbiquitilationUbiquitinationUbiquitinoylationWorkadapter proteinattenuateattenuatesautoimmune conditionautoimmune disorderautoimmunity diseasebiological signal transductioncDNAcytokinedesigndesigninggene inductionhRANKL2in vivoinduction of genesinflamed synovial tissueinflamed synoviuminnovateinnovationinnovativeinsightinterleukin-17Eknock-out animalknockout animalmodel of animalmouse modelmurine modelmutantnovelposttranscriptionalreceptorrecruitrheumatic arthritissOdfsocial rolesynovial inflammationubiquinationubiquitin conjugation
Description preview
Summary
Interleukin-17 (IL-17), a pro-inflammatory cytokine, is pathogenic in autoimmune diseases such as
Inflammatory Arthritis (IA). IA affects more than 1% of the worldwide population and remains incurable to date1.
Ectopic IL17A expression in mice induces IA phenotype and provides a model to study mechanisms2. Activation
of IL-17A receptor…
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