grant
Determine the role of a monocarboxylate transporter in metabolism and intestinal motility
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 31 Mar 2026Deadline 30 Mar 2029
NIHUS FederalResearch GrantFY2026AffectAllelesAllelomorphsAnabolismAnatomic SitesAnatomic structuresAnatomyAnimalsAnteriorAssayAutoregulationBindingBioassayBiologic ModelsBiological AssayBiological ModelsBody TissuesC elegansC. elegansC.elegansCaenorhabditis elegansCalciumCalcium Ion SignalingCalcium OscillationsCalcium SignalingCalcium WavesCancersCardiovascular DiseasesCarnitineCell BodyCell Communication and SignalingCell SignalingCellsCellular MembraneChIP SequencingChIP-seqChIPseqChromosome MappingCommunicationCyclicityDNA mutationDataDefecationDefectDegenerative Neurologic DisordersDiabetes MellitusDietDiseaseDisorderDysfunctionE coliE. coliEquilibriumEscherichia coliFamilyFood DeprivationFood deprivation (experimental)Functional disorderGene AlterationGene LocalizationGene MappingGene Mapping GeneticsGene MutationGeneHomologGenesGenetic ChangeGenetic ModelsGenetic ScreeningGenetic defectGenetic mutationGlycolysisGoalsGoutGrawitz TumorHealthHomeostasisHomologHomologous GeneHomologueHumanHypernephroid CarcinomaHypernephromaHyperuricemiaIntermediary MetabolismIntestinalIntestinal MotilityIntestinesIntracellular Communication and SignalingLigandsLinkLinkage MappingMalignant NeoplasmsMalignant TumorMeasuresMediatingMetabolicMetabolic DiseasesMetabolic DisorderMetabolic PathwayMetabolic ProcessesMetabolismMitochondriaModel SystemModern ManMolecularMolecular InteractionMorphologyMotorMovementMutationNematodaNematodesNephroid CarcinomaNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologicNeurologic Degenerative ConditionsNeurologicalNeuron DegenerationNeuronsNuclear Hormone Receptor SuperfamilyNuclear Hormone ReceptorsOpticsOrganism-Level ProcessOrganismal ProcessPathway interactionsPeriodicityPhenotypePhysiologicPhysiologic ProcessesPhysiologicalPhysiological HomeostasisPhysiological ProcessesPhysiologyPhysiopathologyPlayPoint MutationProcessPropertyProtein FamilyProtein TraffickingProteinsPyruvateRadiolabeledRegulationRenal AdenocarcinomaRenal Cell AdenocarcinomaRenal Cell CancerRenal Cell CarcinomaReporterRhythmicityRoleSignal TransductionSignal Transduction SystemsSignalingSiteStaining methodStainsStressSubstrate SpecificityTestingThesaurismosisTimeTissuesTotal Human and Non-Human Gene MappingUratebalancebalance functionbasolateral membranebiological signal transductionbiosynthesisbody movementbowelbowel movementcardiovascular disorderchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingconfocal imagingdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdeprived of fooddiabetesdietsentire genomeexperimentexperimental researchexperimental studyexperimentsfallsfull genomegene defectgenetic mappinggenome mutationgenome sequencinginsightkidney adenocarcinomamalignancymetabolic profilemetabolism disordermetabolism measurementmetabolomicsmetabonomicsmitochondrialmutantmutant alleleneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronalneuronal degenerationnew approachesnovelnovel approachesnovel strategiesnovel strategyopticalpathophysiologypathwayprogramspromoterpromotorprotein transportradiolabelingradiologically labeledresponseroundwormsocial roletherapeutic targeturicacidemiawhole genome
Description preview
PROJECT SUMMARY
Monocarboxylate transporters (MCTs) mediate the transport of key metabolic intermediates, such as lactate,
urate, and pyruvate, across cellular membranes. Despite their importance in metabolic homeostasis and their
implication in a range of diseases—including cancer, cardiovascular disease, and neurodegeneration—the MCT
family…
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