grant
Determinants of viral assembly and infectivity within the Ebola virus VP24 protein
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 16 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026ActinsAfricaAssayBasal Transcription FactorBasal transcription factor genesBindingBinding SitesBioassayBiochemicalBiochemistryBiological AssayBiological ChemistryBiophysicsCarrier ProteinsCell Communication and SignalingCell Culture TechniquesCell NucleusCell Nucleus Active TransportCell SignalingCellular biologyCessation of lifeCombining SiteComplexCytoplasmCytoplasmic StructuresDNA Molecular BiologyDNA mutationDNA-Dependent RNA PolymerasesDNA-Directed RNA PolymeraseDataDeathDiseaseDisease OutbreaksDisorderEBOVEbola virusEbola-like VirusesEquilibriumExhibitsFamilyFamily memberFatality rateFiloviridaeFilovirusFrequenciesGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenetic ChangeGenetic defectGenetic mutationGenomeGeographyGrowthIFNImmuneImmunesImpairmentImportin-alphaImportin-αInfectionInfection ControlInterferonsIntracellular Communication and SignalingKap95 proteinKaryopherin-beta SubunitMediatingMessenger RNAModelingMolecularMolecular BiologyMolecular InteractionMorphologyMovementMutationNLS ReceptorNLS-Binding ProteinNLSBPNuclearNuclear ExportNuclear ImportNuclear Localization Sequence ReceptorNuclear Localization Signal-Binding ProteinNuclear TranslocationNuclear TransportNucleocapsidNucleocytoplasmic ShuttlingNucleoproteinsNucleusOrthoebolavirusOutbreaksPeptide Signal SequencesPeriodicalsPhosphorylationPlayPolymersProcessProductionProductivityProtein FamilyProtein PhosphorylationProteinsProteomicsRNA PolymerasesRNA VirusesRNA chemical synthesisRNA synthesisReactive SiteRecombinantsRoleSTAT1STAT1 geneSTAT91Signal PeptideSignal SequencesSignal TransductionSignal Transduction SystemsSignalingSiteStructureTestingTissue GrowthTranscription Factor Proto-OncogeneTranscription factor genesTransfectionTransport Protein GeneTransport ProteinsTransporter ProteinTyrosine PhosphorylationViralViral Gene ProductsViral Gene ProteinsViral GenesViral GenomeViral PathogenesisViral ProteinsVirionVirusVirus AssemblyVirus ParticleVirus ReplicationZoonosesZoonoticZoonotic Infectionalpha Karyopherinsantagonismantagonistattenuationbalancebalance functionbeta Importinsbeta Karyopherinsbiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencesbody movementcell biologycell culturecell culturesgenome mutationinsightlive cell imagelive cell imaginglive cellular imagelive cellular imagingmRNAmutantnew approachesnovel approachesnovel strategiesnovel strategynucleocytoplasmic transportontogenyp92 nuclear proteinparticlepathogenperiodicperiodicalpolymerpolymericpolymerizationpreventpreventingprotein protein interactionprotein signal sequencerecombinant virusrecruitresponsesocial rolestructural biologytraffickingtranscription factorviral RNAviral assemblyviral multiplicationviral replicationvirologyvirus RNAvirus genomevirus multiplicationvirus pathogenesisvirus protein
Description preview
Summary
Ebola virus (EBOV), a filovirus, causes periodic outbreaks with high fatality rates. To understand the basis for
viral pathogenesis, emergence, and to devise control strategies, it is important to define the mechanisms that
underlie EBOV assembly and release of infectious virus. The VP24 protein, produced by one of seven viral
genes, is a…
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