grant
Determinants of pegivirus persistence and immune control
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 10 Jul 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdaptive Immune SystemAdoptive TransferAnimal ModelAnimal Models and Related StudiesAntibodiesAntigensAreaB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBiologyBloodBlood Reticuloendothelial SystemBlood SerumCell BodyCell Culture SystemCellsCellular Immune FunctionChronicCommon Rat StrainsDataDefectDiseaseDisorderDysfunctionEvolutionFamilyFlaviviridaeFunctional disorderGlycoproteinsGoalsHBVHCVHIVHealthHepatitis B VirusHepatitis C virusHigh PrevalenceHumanHuman Immunodeficiency VirusesImmuneImmune EvasionImmune SurveillanceImmune TargetingImmune responseImmune systemImmunesImmunityImmunizeImmunocompetentImmunologic SurveillanceImmunologyImmunosurveillanceIn VitroIndividualInfectionKO miceKnock-out MiceKnockout MiceLAV-HTLV-IIILCM VirusesLCMVLaboratory AnimalsLaboratory miceLymphadenopathy-Associated VirusLymphatic cellLymphocyteLymphocyte DepletionLymphocyte SubpopulationsLymphocyte SubsetLymphocyticLymphocytic choriomeningitis virusMaintenanceMammaliaMammalsMediatingMessenger RNAMiceMice MammalsModelingModern ManMolecular CloningMurineMusNull MousePeptidesPersonsPhenotypePhysiopathologyPopulationPredispositionRNA VirusesRatRats MammalsRattusReproducibilityResearchSerumSiteSpleenSpleen Reticuloendothelial SystemSplenocyteSusceptibilitySystemTimeViralViral BurdenViral LoadViral Load resultViremiaVirusVirus-HIVWild Type Mouseacquired immune systemadaptive immunityanti-viral immunityantiviral immunityhost responsehuman pathogenimmune competentimmune evasiveimmune functionimmune system responseimmunogenimmunogenicimmunoresponseknockout genelymph celllymphocyte depletion therapymRNAmodel of animalmouse modelmurine modelnovelpathophysiologypressureresponsereverse geneticstoolviraemiaviral sepsisvirusemiawildtype mouse
Description preview
PROJECT SUMMARY/ABSTRACT
Human pegivirus (HPgV) chronically infects approximately 15% of the global human population. Although HPgV
does not cause overt disease, we know very little about its biology. Currently, there are no cell culture systems
for cultivating HPgV in vitro and no laboratory animals are susceptible to HPgV infection. Recently, we…
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