grant
Detection of Prions
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY20253,4-Dihydroxyphenylacetic Acid3,4-dihydroxy-benzeneacetic acidAD dementiaActive Follow-upAddressAgeAlgorithmsAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's biomarkerAlzheimer's disease biological markerAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmentiaAmyloidAmyloid SubstanceAmyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseAnosmiaAreaArea Under CurveAssayAutonomic nervous systemAutopsyBehaviorBioassayBiological AssayBiological MarkersBiologyBovine Spongiform EncephalitisBovine Spongiform EncephalopathyBrainBrain Nervous SystemCJDCRISPRCRISPR/Cas systemCalciumCalcium Phospholipid-Dependent Protein KinaseCalcium-Activated Phospholipid-Dependent KinaseCardiacCatecholaminesCell Communication and SignalingCell SignalingCerebrospinal FluidCharacteristicsChronic Wasting DiseaseClinicalClinical DataClustered Regularly Interspaced Short Palindromic RepeatsCognitionCognitive DiscriminationCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCohort StudiesConcurrent StudiesCreutzfeldt-Jacob DiseaseCreutzfeldt-Jakob DiseaseCreutzfeldt-Jakob SyndromeCryo-electron MicroscopyCryoelectron MicroscopyDNA mutationDOPACDataData AnalysesData AnalysisDegenerative Neurologic DisordersDementiaDementia with Lewy BodiesDepositDepositionDetectionDevelopmentDiagnosisDiagnosticDiagnostic SensitivityDiagnostic SpecificityDiscriminationDiseaseDisease ProgressionDisorderDisturbance in cognitionDopamineDreamsDrugsEarly DiagnosisEatingElectron CryomicroscopyEncephalonEngineeringEnrollmentEvaluationEventExhibitsFTD dementiaFarm AnimalFilamentFluorescenceFood IntakeFrontal Temporal DementiaFrontotemporal DementiaFutureGehrig's DiseaseGeneticGenetic ChangeGenetic ProcessesGenetic defectGenetic mutationGlutamate ReceptorHeartHomoprotocatechuic AcidHourHumanHydroxytyramineImpaired cognitionIndividualInfectionInfectious Diseases / LaboratoryInfectious Diseases ResearchInternationalIntestinal MucosaIntracellular Communication and SignalingJakob-Creutzfeldt DiseaseKI miceKinasesKineticsKnock-in MouseLB dementiaLB diseaseLB disorderLab FindingsLaboratoriesLaboratory FindingLengthLewy BodiesLewy Body DementiaLewy Body DiseaseLewy Body Type Senile DementiaLewy body disorderLewy dementiaLewy diseaseLewy disorderLinkLivestockLong-term Follow-upLong-term cohort studyLongitudinal cohort studyLongitudinal observation studyLongitudinal, observational studyLou Gehrig DiseaseMT-bound tauMad Cow DiseaseMeasurementMeasuresMedicationMetabolic GlycosylationMethodologyMethodsMiceMice MammalsMinnesotaModelingModern ManMolecularMurineMusMutationMyocardialN-Methyl-D-Aspartate ReceptorsN-Methylaspartate ReceptorsNAC precursorNINDSNMDA Receptor-Ionophore ComplexNMDA ReceptorsNMDA receptor antagonistNational Institute of Neurological Diseases and StrokeNational Institute of Neurological Disorders and StrokeNecrosisNecroticNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuronsObservation researchObservation studyObservational StudyObservational researchOlfactionOlfactory MucosaOlfactory dysfunctionOrthostatic HypotensionOutcomePARK1 proteinPARK4 proteinPRNPParalysis AgitansParkinsonParkinson DiseaseParkinsonianParkinsonian ConditionParkinsonian DiseasesParkinsonian DisordersParkinsonian SyndromeParkinsonismParticipantPathologicPathologyPatient Self-ReportPatientsPharmaceutical PreparationsPharmacodynamicsPhasePhospholipid-Sensitive Calcium-Dependent Protein KinasePhosphorylationPhosphotransferase GenePhosphotransferasesPoliciesPolymersPostural HypotensionPrPPrP ProteinsPrP genePreparednessPrimary ParkinsonismPrimary Senile Degenerative DementiaPrion DiseasesPrion Protein DiseasesPrion ProteinsPrion protein genePrion-Induced DisorderPrionsPrognosisProgressive Supranuclear OphthalmoplegiaProgressive Supranuclear PalsyProtein Kinase CProtein PhosphorylationProtein-Folding DiseasePyramidal neuronRadioactivityReactionReaction TimeReadinessRecombinantsReportingReproducibilityResponse RTResponse TimeRiskRisk FactorsSNCASNCA proteinSOD-1SOD-1 proteinSOD1SOD1 geneSOD1 gene productSamplingScrapieSeizuresSelf-ReportSignal InductionSignal TransductionSignal Transduction SystemsSignalingSiteSkinSmellSmell PerceptionSourceSteele-Richardson-Olszewski DiseaseSteele-Richardson-Olszewski SyndromeStructureSubacute Spongiform EncephalopathySympathinsSynapsesSynapticSynaptic MembranesTauopathiesTestingTimeTransmissible DementiasTransmissible Spongiform EncephalopathiesTransmissionTransphosphorylasesTraumatic encephalopathyUniversitiesUtaha-syna-synucleinabnormally aggregated tau proteinactive followupagesalpha synucleinalpha synuclein genealphaSP22anosphrasiaasynbio-markersbiologic markerbiological signal transductionbiomarkercartilage link proteincerebral spinal fluidcervidchronic traumatic encephalopathyclinical diagnosiscognitive decline in Parkinson'scognitive dysfunctioncognitive dysfunction in Parkinson'scognitive impairment in Parkinson'scognitive losscohortcomputerized data processingcost effectivenesscryo-EMcryoEMcryogenic electron microscopydata interpretationdata processingdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldiagnostic abilitydiagnostic biomarkerdiagnostic capabilitydiagnostic markerdiagnostic powerdiagnostic utilitydiagnostic valuedisease diagnosticdisease durationdisease lengthdrug/agentearly detectionenrollexcitotoxicexcitotoxicityfilamentous tau inclusionfollow upfollow-upfollowed upfollowupfront temporal dementiafrontal lobe dementiafrontotemporal lobar degeneration dementiafrontotemporal lobar dementiafrontotemporal lobe degeneration associated with dementiafundamental researchgenome mutationglycosylationhippocampal pyramidal neuronillness lengthimprovedin vitro Modelindexinginsoluble aggregateknockin micelink proteinlong-term followuploss of smellmicrotubule associated protein tau aggregationmicrotubule associated protein tau depositmicrotubule bound taumicrotubule-bound taumutantnecropsyneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuron toxicityneuronalneuronal degenerationneuronal toxicityneuropathologic tauneuropathological tauneurotoxicitynon A-beta component of AD amyloidnon A4 component of amyloid precursorodor perceptionolfactory impairmentolfactory lossolfactory perceptionorthostatic intolerancepaired helical filamentpaired helical filament of tauphospho-proteomicsphosphoproteomicspolymerpolymericpolymerizationpostmortempredictive assaypredictive testprimary degenerative dementiaprion disorderprion seedsprion-likeprognosticprognostic abilityprognostic powerprognostic utilityprognostic valueprogramsprogression biomarkerprogression markerpropagonsprospectiveprotein aggregateprotein aggregationprotein folding disorderprotein misfolding diseaseprotein misfolding disorderpsychomotor reaction timeputamenradioactivitiesresponseself-aggregate tausenile dementia of the Alzheimer typesexspinal fluidspongiform degenerationspongiform encephalopathysporadic Parkinson's Diseasesuperoxide dismutase 1synapsesynucleinsynucleinopathytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttautau PHFtau Proteinstau accumulationtau aggregatetau aggregationtau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau fibrillizationtau filamenttau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neurofibrillary tangletau neuropathologytau oligomertau paired helical filamenttau pathologytau pathophysiologytau polymerizationtau proteinopathytau related neurodegenerationtau-induced pathologytau-tau interactiontauopathic neurodegenerative disordertauopathytherapeutic agent developmenttherapeutic developmenttime usetransmission processwork groupworking groupα synuclein geneα-synα-synucleinτ Proteinsτ aggregation
Description preview
1) Alpha-synuclein RT-QuIC seed amplification assay (SAA) positivity has been shown to have value as a binary diagnostic biomarker for Parkinson’s disease. However, studies of the prognostic value of this biomarker have been limited to small, single-center studies, with short follow up. We aimed to assess the diagnostic and prognostic value of…
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