grant
Detecting Growth of Intracranial Aneurysms Using Non-Invasive Photon Counting CT in a Murine Model.
NIHUS FederalResearch GrantFY2025Acetylsalicylic AcidAddressAdvocateAlgorithmsAneurysmAnimal ModelAnimal Models and Related StudiesAnimalsAspirinAzovan BlueBloodBlood Reticuloendothelial SystemBlood Vessel ImagingBlood VesselsBody TissuesBrainBrain Nervous SystemBrain VascularBrain imagingCAT scanCD31CD68 antigenCT X RayCT XrayCT imagingCT scanCd68Cerebral AneurysmCerebrumClinicalColoring AgentsComprehensionComputed TomographyContrast AgentContrast DrugsContrast MediaDataDetectionDevelopmentDiagnostic MethodDiagnostic ProcedureDiagnostic TechniqueDiameterDisparitiesDisparityDoseDyesEarly DiagnosisEffectivenessEncephalonEndothelial CellsEnsureEvaluationEvans BlueEvans blue stainFemaleGeneralized GrowthGrowthGuidelinesHealthHistologicHistologicallyHistologyImageImaging ProceduresImaging TechnicsImaging TechniquesImaging technologyImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIntermediary MetabolismInternationalInterventionIntracranial AneurysmLongitudinal StudiesMacrophageMeasurementMetabolic ProcessesMetabolismMethodsMiceMice MammalsMicroscopicModelingMonitorMorphologyMurineMusMφNon-Invasive DetectionNoninvasive DetectionOperative ProceduresOperative Surgical ProceduresOutcomePECAM1PECAM1 genePathologyPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPhotonsPre-Clinical ModelPreclinical ModelsProceduresProtocolProtocols documentationRadiation DoseRadiation Dose UnitRadiation exposureRadiopaque MediaReproducibilityResearchResolutionRiskRoentgen RaysRuptureRuptured AneurysmStaining methodStainsStructureSurgicalSurgical InterventionsSurgical ProcedureSymptomsTechniquesTechnologyTestingTherapeuticTherapeutic EffectTimeTissue GrowthTissuesTomodensitometryTrainingVariantVariationVisualizationX-RadiationX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyX-Ray RadiationX-rayXrayXray CAT scanXray Computed TomographyXray computerized tomographyanimal databrain visualizationcatscancerebralcerebral arterycerebral vascularcerebro-vascularcerebrovascularcohortcomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographycostcost effectivedeep learning based modeldeep learning modeldetectordetermine efficacydevelopmentalearly detectionefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationenzyme activityevaluate efficacyexamine efficacyhigh resolution imaginghuman dataimage constructionimage generationimage reconstructionimage-based methodimagingimaging methodimaging modalityimprovedin vivoindividualized therapeuticinnovateinnovationinnovativeinsightintracranial arterylong-term studylongitudinal outcome studiesmalemodel of animalmouse modelmulti-modalitymultimodalitymurine modelnon-contrast CTnon-invasive diagnosisnon-invasive diagnosticnon-invasive imagingnon-invasive monitornoncontrast CTnoncontrast computed tomographynoninvasive diagnosisnoninvasive diagnosticnoninvasive imagingnoninvasive monitornovelontogenypatient oriented outcomespersonalization of treatmentpersonalized medicinepersonalized therapeuticpersonalized therapypersonalized treatmentpre-clinicalpreclinicalresolutionsresponsesexsex related variationsex variablesex variationsex-related variablesurgerytooltreatment strategyvaries by sexvascularvascular imagingvasculature Imaging♀♂
Description preview
Abstract: Unruptured intracranial aneurysms (UIAs), particularly those between 3-7 mm in diameter, present
significant clinical challenges due to their potential for growth and rupture. Early and accurate detection is
critical for effective management, as current invasive interventions carry substantial risks and costs. Emerging
evidence suggests…
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