grant
Designing cell-instructive viscoelastic hydrogels to understand and exploit mechanobiology
Organization UNIVERSITY OF VIRGINIALocation CHARLOTTESVILLE, UNITED STATESPosted 15 Mar 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY20263-D3-D modeling3-Dimensional3D3D cell culture3D culture3D modelingArchitectureB-Cell Differentiation Factor GeneB-Cell Stimulatory Factor 2 GeneBSF-2 GeneBSF2 GeneBeta-2 Gene InterferonBiocompatible MaterialsBiomaterialsBody TissuesCell BodyCell FunctionCell LineCell PhysiologyCell ProcessCell SurvivalCell ViabilityCell-Extracellular MatrixCellLineCellsCellular FunctionCellular MechanotransductionCellular PhysiologyCellular ProcessComplexCuesDataDevelopmentDiseaseDisease ProgressionDisorderECMEngineering / ArchitectureEnvironmentEsteroproteasesExhibitsExtracellular MatrixFibroblastsHSF GeneHepatocyte Stimulatory Factor GeneHeterogeneityHourHybridoma Growth Factor GeneHydrogelsIFNB2 GeneIL-6 GeneIL6IL6 geneImmuneImmunesImmunomodulationInflammatoryInterleukin 6 (Interferon, Beta 2) GeneInterleukin-6 GeneKnock-outKnockoutKnowledgeLightMMPsMacrophageMatrix MetalloproteinasesMechanical Signal TransductionMechanicsMechanosensory TransductionModelingMφOutcomePatientsPatternPeptidasesPeptide HydrolasesPhotoradiationPrintingPropertyProtease GeneProteasesProteinasesProteolytic EnzymesRelaxationRheologyRoleShapesStrains Cell LinesStressStromal CellsStructureSubcellular ProcessSystemTissue ModelTissuesWorkWound Repairbio-printingbiological materialbiomaterial developmentbioprintingcell behaviorcellular behaviorcrosslinkcultured cell linedesigndesigningdevelopmentaldigitalfabricationimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimprovedin vivoinventionmechanicmechanicalmechanical cuemechanical signalmechanosensingmechanotransductionnano indentationnanoindentationregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueresponsesocial rolespatial RNA sequencingspatial and temporalspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial temporalspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsspatiotemporalthree dimensionalthree dimensional cell culturethree-dimensional modelingtissue regenerationtissue regrowthtissue renewaltissue specific regenerationviscoelasticitywound healingwound recoverywound resolution
Description preview
ABSTRACT
Tissues exhibit spatially heterogeneous viscoelastic mechanics during development, disease progression, and
wound repair, but dissecting how viscoelasticity regulates in vivo phenomena remains challenging. This MIRA
tackles this key challenge through the invention of the first hydrogel 3D cell culture platform with
photopatterned…
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