grant
Design of an integrated microdevice to measure malignant lipid signaling in single cells from clinical samples
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY20260-11 years old21+ years oldAML - Acute Myeloid LeukemiaAcute Myeloblastic LeukemiaAcute Myelocytic LeukemiaAcute Myelogenous LeukemiaAddressAdultAdult AGLAdult AMLAdult ANLLAdult Acute Granulocytic LeukemiaAdult Acute Myeloblastic LeukemiaAdult Acute Myelocytic LeukemiaAdult Acute Myelogenous LeukemiaAdult Acute Myeloid LeukemiaAdult Acute Non-Lymphoblastic LeukemiaAdult Acute Non-Lymphocytic LeukemiaAdult Acute NonLymphoblastic LeukemiaAdult Acute NonLymphocytic LeukemiaAdult HumanAgeAllogenicApoptosisApoptosis PathwayApoptoticAssayBehaviorBioassayBiochemicalBiological AssayBiomedical EngineeringCancer TreatmentCancersCell BodyCell Communication and SignalingCell DeathCell LineCell SignalingCellLineCellsCellular AssayCellular ExpansionCellular GrowthChemistryChildChild YouthChildhood AMLChildhood Acute Granulocytic LeukemiaChildhood Acute Myeloblastic LeukemiaChildhood Acute Myelocytic LeukemiaChildhood Acute Myelogeneous LeukemiaChildhood Acute Myelogenous LeukemiaChildhood Acute Myeloid LeukemiaChildhood LeukemiaChildren (0-21)ChromatographyClinicalCytogeneticsDNA cassetteDNA mutationDataDehydrogenasesDevelopmentDevicesDiseaseDisorderDrug CombinationsDrug TargetingDrug TherapyDrug resistanceDrugsEngineeringEnsureEnzyme ActivationEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEvolutionFDA approvedFLK2FLT3FLT3 geneFMS-like tyrosine kinase 3Fatty AcidsFms-Related Tyrosine Kinase 3FutureGeneralized GrowthGeneticGenetic ChangeGenetic DifferentiationGenetic DivergenceGenetic DriftGenetic HeterogeneityGenetic defectGenetic mutationGrowthHeterogeneityIn complete remissionInositide PhospholipidsInositol PhosphoglyceridesInositol PhospholipidsInterdisciplinary ResearchInterdisciplinary StudyIntermediary MetabolismInternationalIntracellular Communication and SignalingInvestigatorsKinasesLab On A ChipLaboratoriesLecithinasesLipid BiochemistryLipidsMalignantMalignant - descriptorMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMeasurementMeasuresMedicationMetabolicMetabolic ProcessesMetabolismMicrofabricationMole the mammalMolesMultidisciplinary CollaborationMultidisciplinary ResearchMutateMutationOncogenicOncologyOncology CancerOxidoreductaseOxidoreductase GenePathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPediatric AMLPediatric Acute Myeloblastic LeukemiaPediatric Acute Myelocytic LeukemiaPediatric Acute Myelogeneous LeukemiaPediatric Acute Myelogenous LeukemiaPediatric Acute Myeloid LeukemiaPediatric LeukemiaPerformancePharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhosphatidesPhosphatidyl InositolPhosphatidylinositolsPhosphoinositidesPhospholipasePhospholipidsPhosphotransferase GenePhosphotransferasesPhysiologyPlayProcessProgenitor Cell TransplantationPrognosisProgrammed Cell DeathProteinsProtocolProtocols documentationPtdInsRecurrenceRecurrentReductasesRelapseReporterResearch PersonnelResearchersResistanceResistance developmentResistant developmentRisk AssessmentRoleSTK-1 kinaseSTK1SamplingSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSphingolipidsStem Cell TransplantationStem Cell Tyrosine Kinase 1Stem cell transplantStrains Cell LinesSurvival RateSystemTechniquesTechnologyTherapeuticTherapeutic AgentsThin Layer ChromatographyTissue GrowthTransphosphorylasesTransplantationTumor CellVariantVariationWorkacute granulocytic leukemiaacute granulocytic leukemia cellacute myeloblastic leukemia cellacute myelocytic leukemia cellacute myelogenous leukemia cellacute myeloid leukemiaacute myeloid leukemia cellacute nonlymphocytic leukemia celladulthoodagesanti-cancer therapybio-engineeredbio-engineersbioengineeringbiological engineeringbiological signal transductioncancer therapycancer-directed therapycell assaycell behaviorcell growthcellular behaviorchemotherapychildren with AMLchildren with acute myeloid leukemiachildren with leukemiaclinical remissionco-morbidco-morbiditycomorbiditycomplete responsecultured cell linecustomized therapycustomized treatmentdesigndesigningdeveloping resistancedevelopmentaldevice miniaturizationdrug efficacydrug interventiondrug resistantdrug treatmentdrug/agentenhancer cassetteenzyme activityepigeneticallyepigenomeexperimentexperimental researchexperimental studyexperimentsexpression cassettefetal liver kinase-2fetal liver kinase-3gene cassettegenetic cassettegenome mutationglobal gene expressionglobal transcription profileimprovedindividual patientindividualized medicineindividualized patient treatmentindividualized therapeuticindividualized therapeutic strategyindividualized therapyindividualized treatmentinnovateinnovationinnovativeinstrumentinstrumentationintegration cassettekidslab on chipleukemialeukemia in childrenmalignancymetabolomemetabonomemicrodevicemicrofabricated deviceminiaturizeminiaturizedminiaturized deviceminiaturized electronicsminiaturized technologiesnanofabricatenanofabricationnecrocytosisneoplasm/cancerneoplastic cellnew technologynon-geneticnongeneticnovelnovel technologiesontogenyoverexpressoverexpressionpathwaypatient oriented outcomespatient specific therapiespatient specific treatmentpersonalized therapeuticpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspoint of careprecision medicineprecision-based medicineprogenitor transplantationprogramspromoter cassettereporter cassetteresistance cassetteresistance to Drugresistance to therapyresistantresistant to Drugresistant to therapyresponseselectable cassetteselection cassettesilica gelsilochromesingle cell analysissocial rolestem and progenitor cell transplantationsstop cassettetailored medical treatmenttailored therapytailored treatmenttargeted cancer therapytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic resistancetherapy optimizationtherapy resistanttranscription cassettetranscriptional cassettetranscriptometransgene cassettetransplanttreatment optimizationtreatment resistancetumorunique treatmentvirtualyoungster
Description preview
PROJECT SUMMARY / ABSTRACT
Engineering advances applied to miniaturized analytical instrumentation will be employed to improve
sensitivity and throughput of thin-layer chromatography enabling single-cell analyses of the biochemical
activity of lipid modifying enzymes in the cells of patients. By utilizing micro- and nanofabrication techniques,
the…
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