grant
Deoxyuridine Contamination and Innate Immune Signaling
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 3 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026(IFN) α(IFN)-α(IFN)αAddressAffinity ChromatographyAfter CareAfter-TreatmentAftercareAlferonAntimetabolitesBase Excision RepairsBase PairingBindingBinding ProteinsCancer ModelCancer PatientCancerModelCell BodyCell Communication and SignalingCell CycleCell Cycle CheckpointCell Cycle InhibitionCell Division CycleCell LineCell SignalingCellLineCellsCheckpoint inhibitorCytoplasmDNADNA Base Excision RepairDNA DamageDNA Damage RepairDNA InjuryDNA IntegrationDNA Polymerase IIDNA Polymerase epsilonDNA PolymerasesDNA RepairDNA ReplicationDNA SynthesisDNA biosynthesisDNA-Dependent DNA Polymerase IIDNA-Dependent DNA PolymerasesDNA-Dependent RNA Polymerase IIIDNA-Directed DNA PolymeraseDataDehydrogenasesDeoxyribonucleic AcidDeoxyuridineDoseDouble-Stranded DNAEndogenous Interferon BetaFibroblast InterferonFluorescenceGene TranscriptionGenetic TranscriptionGenomic DNAIFN AlphaIFN αIFN-αIFN-βIFNaIFNbIFNαImmune checkpoint inhibitorImmune mediated therapyImmune responseImmune signalingImmunologic ReceptorsImmunological ReceptorsImmunologically Directed TherapyImmunotherapyIn VitroInnate Immune ResponseInterferon Alfa-n3Interferon-αInterferon-βIntracellular Communication and SignalingIonizing Electromagnetic RadiationIonizing radiationKO miceKinasesKineticsKnock-outKnock-out MiceKnockoutKnockout MiceLeukocyte InterferonLigand Binding ProteinLigand Binding Protein GeneLigandsLymphoblast InterferonLymphoblastoid InterferonMiceMice MammalsModelingMolecular InteractionMultitargeted AntifolateMurineMusNatural Interferon BetaNatural human interferon betaNon-Polyadenylated RNANull MouseOxidoreductaseOxidoreductase GenePatientsPattern RecognitionPattern recognition receptorPemetrexedPhosphotransferase GenePhosphotransferasesPol IIPolymeraseProtein BindingPublishingRARRES3RARRES3 geneRIG1RNARNA ExpressionRNA Gene ProductsRNA NucleasesRNA Polymerase CRNA Polymerase IIIRNaseRadiation-Ionizing TotalReceptor SignalingReductasesReplication UnitRepliconReporterRibonuclease Family ProteinRibonucleasesRibonucleic AcidSignal TransductionSignal Transduction SystemsSignalingStrains Cell LinesSystemTIG3TMP synthetaseThymidinThymidineThymidylate SynthaseThymidylate SynthetaseTobacco-Associated CarcinogenTranscriptionTransfectionTransphosphorylasesUng DNA glycosylaseUnscheduled DNA SynthesisUra-DNA glycosidaseUra-DNA glycosylaseaffinity purificationaptamerbasebasesbiological signal transductionbound proteincell cycle check pointchemotherapycultured cell linedTMP Synthaseds-DNAdsDNAexperimentexperimental researchexperimental studyexperimentsgDNAhost responsehypoimmunityimmune check point inhibitorimmune deficiencyimmune microenvironmentimmune receptorimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunodeficiencyimmunoresponseimmunosuppressive microenvironmentimmunosuppressive tumor microenvironmentinhibitorinnovateinnovationinnovativeionizing outputknock-downknockdownmicronucleusmouse modelmurine modelpost treatmentrepairrepairedresponsestandard of caretargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttobacco carcinogentobacco related carcinogentobacco specific carcinogentumortumor immune microenvironmenttumor-immune system interactionsuracil N-glycosidaseuracil N-glycosylaseuracil-DNA glycosidaseuracil-DNA glycosylase
Description preview
ABSTRACT
Most chemotherapies target DNA replication, and their efficacy depends on the DNA damage response that
integrates DNA repair with the cell cycle. Widely used standard-of-care antimetabolites inhibit thymidylate
synthase and increase the incorporation of deoxyuridine (dU) into DNA by polymerases. dU contamination in
DNA is limited by the…
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