grant
Defining virulence factor functions using minimal pathogen genomes
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 10 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026Abdominal TyphusAgricultureAnimal ModelAnimal Models and Related StudiesArchitectureAreaBacteriaBacterial Gene ProductsBacterial Gene ProteinsBacterial ProteinsBiochemicalBiochemistryBioinformaticsBiological ChemistryBody TissuesCell BodyCell ComponentsCell FunctionCell PhysiologyCell ProcessCell StructureCell modelCellsCellular FunctionCellular Immune FunctionCellular PhysiologyCellular ProcessCellular StructuresCellular modelCommunicable DiseasesComplexCytometryCytoplasmDNA mutationDataDevelopmentDiseaseDisorderDrug TargetingEmerging Communicable DiseasesEmerging Infectious DiseasesEngineeringEngineering / ArchitectureEnsureEnteric FeverEnvironmentEventFamilyGTP PhosphohydrolasesGTPasesGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenomeGenotypeGleanGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesHost Defense MechanismHumanImmuneImmune systemImmunesImmunityImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsIndividualInfectionInfectious DiseasesInfectious DisorderInnate ImmunityInvestigationKO miceKnock-out MiceKnockout MiceKnowledgeL pneumophilaL. pneumophilaLaboratoriesLegionella pneumophilaLinkLipidsLocationMasksMediatingMembraneMethodologyMiceMice MammalsModelingModern ManMolecularMultienzyme ComplexesMurineMusMutationNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityNull MouseNutrientOperonOrganismPathogenesisPathogenicityPathogenicity FactorsPhenotypePhysiologicPhysiologicalPlayProcessProteinsRegulationResearch ResourcesResolutionResourcesRoleS entericaS enterica serovar TyphimuriumS typhimuriumS. entericaS. enterica TyphimuriumS. enterica serovar TyphimuriumS. typhimuriumSalmonellaSalmonella entericaSalmonella enterica TyphimuriumSalmonella enterica serovar TyphimuriumSalmonella infectionsSalmonella typhimuriumSalmonellosisSeriesStructureSubcellular ProcessSystemSystemic diseaseT3SST4SSTechnologyTestingTimeTissuesType III Secretion SystemType III Secretion System PathwayType IV Secretion SystemType IV Secretion System PathwayTyphoidTyphoid FeverVacuoleVirulenceVirulence FactorsWorkbacteria pathogenbacterial geneticsbacterial pathogencell typecombatdesigndesigningdevelopmentalenzyme complexgene functiongene networkgenome mutationguanosinetriphosphatasehuman diseaseimmune functionin vivoin vivo Modelinnovateinnovationinnovativeinsightlive cell imagelive cell imaginglive cellular imagelive cellular imagingliving systemloss of function mutationmembrane biogenesismembrane structuremodel of animalmouse modelmurine modelnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnon-typhoid Salmonellanon-typhoidal Salmonellanovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetparticlepathogenpathogen genomepathogenic bacteriapathogenomeprotein functionresolutionssingle cell technologysingle moleculesocial rolespatial and temporalspatial temporalspatiotemporaltheoriestraffickingtype 3 secretion systemtype 4 secretion system
Description preview
Project Summary
Pathogenic bacteria have developed an array of strategies to undermine the host's defense mechanisms. In
the context of non-Typhoidal Salmonella Typhimurium, a notable strategy involves the confinement of a single
bacterium within a host vacuole called the Salmonella Containing Vacuole (SCV). This approach potentially
provides an…
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