grant
Defining Tumor Microenvironmental Interactions that drive THY1-Mediated Treatment Resistance in Glioblastoma
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Mar 2024Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAfter CareAfter-TreatmentAftercareAutomobile DrivingAwardBindingBioinformaticsBiologic ModelsBiologicalBiological ModelsBiometricsBiometryBiostatisticsBlood VesselsBusiness-Friendly AtmosphereCD97CD97 geneCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCancer BiologyCancer CenterCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCas nuclease technologyCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell Surface ReceptorsCell-to-Cell InteractionCellsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyDataDevelopmentDichloromethylene DiphosphonateDiseaseDisorderEnsureExhibitsExpression SignatureFoundationsGene ExpressionGene Expression ProfileGenomicsGlial Cell TumorsGlial NeoplasmGlial TumorGlioblastomaGliomaGoalsGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaGrantHeterogeneityHumanIn VitroIn vivo analysisInstitutionIntegrinsIntegrins Extracellular MatrixInternationalIntracellular Communication and SignalingK-AwardsK-Series Research Career ProgramsKnock-outKnockoutLigandsMacrophageMediatingMediatorMentorsMentorshipMesenchymalMichiganModel SystemModelingModern ManMolecularMolecular InteractionMφNeuroglial NeoplasmNeuroglial TumorOncologyOncology CancerPDX modelPathway interactionsPatient derived xenograftPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPhenotypePopulationPrimary Brain NeoplasmsPrimary Brain TumorsProductivityProgenitor CellsProteinsPublishingRadiationRadioresistanceRecurrenceRecurrentRecurrent NeoplasmRecurrent tumorResearchResearch Career ProgramResearch EthicsResistanceRoleSamplingScientistSignal TransductionSignal Transduction SystemsSignalingStem Cell likeSystemTemodalTemodarTestingTrainingTranscription AlterationTumor BiologyTumor CellUniversitiesUpregulationWorkWritingadulthoodbiologicbiological signal transductionbusiness-friendly environmentcancer genomicscancer microenvironmentcancer typecareercareer developmentclinical databaseclinical relevanceclinical trainingclinically relevantclodronatecollaborative atmospherecollaborative environmentdesigndesigningdevelopmentaldrivingexperimentexperimental researchexperimental studyexperimentsgene expression patterngene expression signatureglial-derived tumorglioblastoma multiformeimprovedin vivoin vivo Modelin vivo evaluationin vivo testinginnovateinnovationinnovativeinteractive atmosphereinteractive environmentinterdisciplinary atmosphereinterdisciplinary environmentmethazolastonemultiomicsmultiple omicsneoplasm recurrenceneoplastic cellneuroglia neoplasmneuroglia tumorneurosurgerynew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapeuticsnew therapynew therapy approachesnew therapy targetnew treatment approachnew treatment strategynext generation therapeuticsnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy approachnovel therapy targetoncogenomicsoverexpressoverexpressionpanomicspathwaypatient derived xenograft modelpatient oriented outcomespeer-group atmospherepeer-group environmentpost treatmentprofessorprogenitor capacityprogenitor cell geneprogenitor cell likeprogenitor cell markersprogenitor geneprogenitor markersprogenitor stem cell markersprogenitor-likeprogramsradiation resistanceradio resistanceresistance mechanismresistance to therapyresistantresistant mechanismresistant to therapyscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell analysissingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsspongioblastoma multiformestandard of carestem cell biomarkersstem cell characteristicsstem cell genesstem cell markersstem cellsstem-likestemnesssuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttemozolomidetherapeutic resistancetherapy resistanttranscriptional profiletranscriptional signaturetreatment resistancetumortumor microenvironmentvascular
Description preview
This K08 proposal will complete Dr. Wajd Al-Holou’s training towards his long-term career goal of directing an
independent research program that aims to define critical cellular interactions in the tumor microenvironment
that drive treatment resistance in glioblastoma (GBM) and ultimately identify therapies targeting mechanisms of
resistance. Dr.…
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