grant
Defining the Rules for Pioneer Factor Nucleosome Engagement
Organization STATE UNIVERSITY OF NEW YORK AT BUFFALOLocation AMHERST, UNITED STATESPosted 20 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AssayBasal Transcription FactorBasal transcription factor genesBehaviorBindingBinding ProteinsBinding SitesBioassayBiologicalBiological AssayBiological FunctionBiological ProcessCell BodyCell LineCell modelCellLineCellsCellular modelCharacteristicsChromatinChromosome SegregationCombining SiteDNADNA BindingDNA Binding InteractionDNA Damage RepairDNA MethylationDNA RecombinationDNA RepairDNA ReplicationDNA SynthesisDNA biosynthesisDNA boundDeoxyribonucleic AcidDevelopmentDevelopmental ProcessDiseaseDisorderDissectionEventGene ActivationGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic RecombinationGenetic TranscriptionGenomeGoalsHistonesIn VitroKnowledgeLigand Binding ProteinLigand Binding Protein GeneMissionModelingMolecular InteractionNational Institutes of HealthNatureNucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesNucleosomesOrganismPositionPositioning AttributeProtein BindingPublic HealthRNA ExpressionReactive SiteRecombinationRegulatory ElementRegulatory RegionsResearchStrains Cell LinesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationUnited States National Institutes of HealthUnscheduled DNA SynthesisVariantVariationbiologicbound proteinchromatin remodelingchromosome divisioncombatcultured cell linedevelopmentaldisease modeldisorder modelgenetic regulatory elementhistone modificationinsightliving systemtranscription factor
Description preview
DNA binding to chromosomal DNA is essential for many fundamental biological processes
including: transcriptional regulation, DNA replication and repair, recombination, and chromosome
segregation. There is a fundamental gap in understanding how transcription factors (TF) bind
regulatory regions located in compacted, high-order chromatin. Therefore,…
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