grant
Defining the role of lncRNA Neat1 and the nuclear paraspeckle in regulating macrophage innate immune gene expresison
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2026AblationActive Follow-upAgonistArchitectureBioavailabilityBiological AvailabilityBiotinBone MarrowBone Marrow Reticuloendothelial SystemCatalogsCategoriesCell BodyCell LineCell NucleolusCell NucleusCellLineCellsCellular StressCellular Stress ResponseChemotactic CytokinesDataEngineering / ArchitectureEnsureGene ExpressionGene TranscriptionGenesGenetic TranscriptionGoalsGuide RNAHeLaHela CellsHeterogeneous-Nuclear Ribonucleoprotein Group MHeterogeneous-Nuclear Ribonucleoprotein MHigh Throughput AssayHomologous Chemotactic CytokinesHourHydrophobicityHypoxiaHypoxicIFNImmuneImmune Cell ActivationImmune PrecipitationImmune responseImmunesImmunofluorescence MicroscopyImmunoprecipitationIn SituInfection ControlInflammatoryInflammatory ResponseInnate Immune ResponseIntercrinesInterferonsKinasesKineticsLabelLipopolysaccharidesMacrophageMacrophage ActivationMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMediatorModelingMolecularMφNuclearNuclear ProteinsNuclear RNANucleic AcidsNucleusOligoOligonucleotidesOsmosisOutcomeOxygen DeficiencyPathway interactionsPhasePhosphotransferase GenePhosphotransferasesPhysical condensationPhysiologic AvailabilityPlasmosomePre-mRNAProteinsProteomeRNA EditingRNA ExpressionRNA ProcessingRNA SeqRNA SplicingRNA sequencingRNA, Messenger, EditingRNA, Messenger, PrecursorsRNA-Binding ProteinsRNAseqRoleS entericaS enterica serovar TyphimuriumS typhimuriumS. entericaS. enterica TyphimuriumS. enterica serovar TyphimuriumS. typhimuriumSIS cytokinesSalmonella entericaSalmonella enterica TyphimuriumSalmonella enterica serovar TyphimuriumSalmonella typhimuriumShort interfering RNASignaling MoleculeSmall Interfering RNASpinal ColumnSpineSplicingStimulusStrains Cell LinesStressStructureStudy modelsTimeTranscriptTranscriptionTransmissionTransphosphorylasesVSVVertebral columnVesicular Stomatitis VirusVesicular stomatitis Indiana virusVitamin Hactive followupanti-microbialantimicrobialbackbonecandidate identificationcatalogcell stresscell typechemoattractant cytokinechemokinecoenzyme Rcohortcondensationcultured cell linecytokineexosomeexperimentexperimental researchexperimental studyexperimentsfollow upfollow-upfollowed upfollowupgRNAgene synthesishigh throughput screeninghnRNP Mhost responsehydrophilicityimmune activationimmune system responseimmunopathologyimmunoresponseinhibitorinsightinterestmRNA ExportmRNA Precursornovelnucleolusoligospathogenpathwayphysiologic stressesphysiologic stressorphysiological stressesposttranscriptionalrecruitresponsescreeningscreeningssiRNAsocial rolesodium arsenitesodium metaarsenitestressortranscriptome sequencingtranscriptomic sequencingtransmission process
Description preview
PROJECT SUMMARY
To ensure a robust immune response to pathogens without risking immunopathology, the kinetics and
amplitude of inflammatory gene expression in macrophages need to be exquisitely well-controlled. To mount
balanced inflammatory responses, macrophages need to be able to coordinate the transcription and
processing of thousands of genes…
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