grant
Defining the role of lipid metabolism in nuclear envelope identity and dynamics
NIHUS FederalResearch GrantFY20251,2-diacylglycerol3-D3-Dimensional3-sn-Phosphatidate phosphohydrolase3DActive Follow-upAcuteAmino AcidsAssayBindingBinding ProteinsBioassayBiological AssayBiosensorCancersCell BodyCell Membrane LipidsCell NucleusCellsChromosome SegregationCodeCoding SystemDNA mutationDataDefectDiacylglycerolsDiglyceridesDiseaseDisorderEndoplasmic ReticulumEnvelope ProteinEnvironmentEnzyme GeneEnzymesErgastoplasmFundingGeneralized GrowthGenetic ChangeGenetic DiseasesGenetic defectGenetic mutationGenomeGrowthHeadHumanHuman GeneticsHuman PathologyHutchinson-Gilford DiseaseHutchinson-Gilford SyndromeImageIn VitroIntegral Membrane ProteinIntrinsic Membrane ProteinLeadLigand Binding ProteinLigand Binding Protein GeneLipid BilayersLipid BindingLipid ChemistryLipidsLipodystrophyLiposomalLiposomesM PhaseMalignant NeoplasmsMalignant TumorMembraneMembrane LipidsMetabolicMitosisMitosis StageMitoticModern ManMolecularMolecular InteractionMuscleMuscle TissueMuscular DystrophiesMutationMutation AnalysisMyodystrophicaMyodystrophyNuclearNuclear EnvelopeNuclear Inner MembraneNuclear MembraneNucleusOrganellesPathway interactionsPatternPb elementPhosphatidate PhosphatasePhosphatidate PhosphohydrolasePhosphatidic Acid PhosphatasePhosphatidic Acid PhosphohydrolasePhosphoprotein PhosphatasePhosphoprotein Phosphatase-2CPhosphoprotein PhosphohydrolasePremature Senility SyndromeProcessProgeriaProtein BindingProtein Phosphatase CProtein Phosphatase GeneProtein Phosphatase-1Protein Phosphatase-2AProtein phosphataseProteinsRegulationResolutionRoleSiteSpecific qualifier valueSpecifiedStructureTestingTissue GrowthTransmembrane ProteinTransmembrane Protein GeneWorkYeastsaccelerated agingaccelerated biological ageaccelerated biological agingactive followupage accelerationaminoacidbiological sensorbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiesbound proteinchromosome divisiondiacylglyceroldiglycerideenv Antigensenv Gene Productsenv Polyproteinsenv Proteinexperimentexperimental researchexperimental studyexperimentsfat metabolismfollow upfollow-upfollowed upfollowupgenetic conditiongenetic disordergenome integritygenome mutationgenomic integrityheavy metal Pbheavy metal leadhuman diseaseimagingin vivolipid bilayer membranelipid boundlipid metabolismlipidomicslipinlipinemalignancymembrane biogenesismembrane structuremuscle dystrophymuscularnano meter scalenano meter sizednanometer scalenanometer sizednanoscaleneoplasm/cancerontogenypathwayresolutionsscreeningscreeningssealsocial rolesuperresolution imagingthree dimensionaltissue/cell culturetool
Description preview
PROJECT ABSTRACT
The nuclear envelope is a distinct domain of the endoplasmic reticulum (ER) that serves to surround and protect
the genome. The unique identity of the nuclear envelope is determined by a subset of integral membrane proteins
that execute its distinct functions. After each open mitosis, the nuclear envelope must regain its identity…
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