grant
Defining the Role of HPV Integration Structures in HNSCC Molecular Heterogeneity
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Aug 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025ATACATAC sequencingATAC-seqATACseqAdoptionAssay for Transposase-Accessible Chromatin using sequencingBiologicalBiological MarkersCRISPRCRISPR/Cas systemCancersCell BodyCell LineCellLineCellsCharacteristicsChromatinClinicalClinical TrialsClonalityClustered Regularly Interspaced Short Palindromic RepeatsDNADNA seqDNA sequencingDNAseqDataDeoxyribonucleic AcidDetectionDevelopmentDiseaseDisorderElementsEngineeringEpidemicEventFutureGene TranscriptionGenesGeneticGenetic TranscriptionGenomicsGoalsHNSCCHPVHPV associated HNSCCHPV associated OPSCCHPV driven HNSCCHPV driven head and neck cancerHPV infectionHPV positiveHPV positive OPSCCHPV positive oropharyngeal squamous cell carcinomaHPV related OPSCCHPV related oropharyngeal squamous cell carcinomaHPV(+)HPV(+) HNSCCHPV(+) head and neck squamous cell carcinomaHPV+HPV+ HNSCCHPV+ OPSCCHPV+ head and neck cancersHPV+ oropharyngeal squamous cell carcinomaHPV-associated head and neck cancerHPV-associated head and neck squamous cell carcinomaHPV-positive HNSCCHPV-positive head and neck cancersHPV-related HNSCCHPV-related head and neck squamous cell carcinomaHead and Neck Squamous Cell CarcinomaHeterogeneityHuman Papilloma VirusHuman PapillomavirusHuman papilloma virus infectionHuman papillomavirus driven HNSCCHuman papillomavirus driven head and neck cancerHuman papillomavirus infectionIndividualInfectious Human Wart VirusInformaticsKnowledgeLPTNLinkLocationMachine LearningMalignant NeoplasmsMalignant TumorModelingMolecularMorbidityMorbidity - disease rateOutcomePathogenicityPatientsPhenotypePublic HealthPublishingRNA ExpressionRNA SeqRNA sequencingRNAseqRecurrenceRecurrentResearchResearch ResourcesResearch SpecimenResourcesRoleSCCHNSCM-1SCM-1aSCM1SCYC1Sensitivity and SpecificitySpecimenStrains Cell LinesStructural ModelsStructureTechnologyTestingTranscriptTranscriptionTreatment FailureTreatment outcomeUnited StatesVaccinesViralXCL1XCL1 geneassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbio-markersbiologicbiologic markerbiomarkercancer cell genomecancer genomecancer progressioncohortcultured cell linedevelopmentalgene functiongenome sequencingglobal gene expressionglobal transcription profilehead and neck squamous carcinomahead and neck squamous cell cancerhuman papilloma virus oropharyngeal squamous cell carcinomahuman papilloma virus+ head and neck squamous cell carcinomahuman papilloma virus+ oropharyngeal squamous cell carcinomahuman papillomavirus +human papillomavirus associated head and neck cancerhuman papillomavirus associated head and neck squamous cell carcinomahuman papillomavirus associated oropharyngeal squamous cell carcinomahuman papillomavirus associated oropharynx squamous cell carcinomahuman papillomavirus driven head and neck squamous cell carcinomahuman papillomavirus induced head and neck squamous cell carcinomahuman papillomavirus positivehuman papillomavirus positive HNSCChuman papillomavirus positive head and neck cancershuman papillomavirus positive head and neck squamous cell carcinomahuman papillomavirus positive oropharyngeal squamous cell carcinomahuman papillomavirus related head and neck squamous cell carcinomahuman papillomavirus related oropharyngeal squamous cell carcinomaimprovedintegration sitemachine based learningmalignancyneoplasm progressionneoplasm/cancerneoplastic progressionnew technologynovelnovel technologiesoral HPV-positive HNSCCoral HPV-positive head and neck cancersoral human papillomavirus positive head and neck cancersoral human papillomavirus positive head and neck squamous cell carcinomapresence of HPVpresence of human papillomavirusprognostic abilityprognostic powerprognostic utilityprognostic valueprognosticationprogramssocial rolesuccesstech developmenttechnology developmenttherapy failuretranscriptometranscriptome sequencingtranscriptomic sequencingtreatment risktumortumor genometumor progressionwart virus
Description preview
Abstract: HPV positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC) comprises a progressively
rising epidemic that will be a public health problem for several decades both because of the persistently low
adoption of the vaccine in the United States and the delay from HPV infection to the development of malignancy.
For this disease, treatment…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click