grant
Defining the Role of Enteric Nervous System Dysfunction in Gastrointestinal Motor and Sensory Abnormalities in Down Syndrome
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 1 May 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY202621+ years oldAD dementiaAberrant ChromosomeAcid RefluxAddressAdultAdult HumanAffectAganglionic MegacolonAllergic to foodAllergy to foodAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnimal Experimental UseAnimal ExperimentationAnimal ResearchAutoimmune DiseasesAutoimmune StatusAutoimmunityBehaviorBiologicalBypassCancersChildhoodChromosomal AberrationsChromosomal AbnormalitiesChromosomal AlterationsChromosome AberrationsChromosome AlterationsChromosome AnomaliesChromosome abnormalityChronicClinicalClinical ManagementCognitionCohort StudiesColonColonic inflammationCongenital MegacolonConstipationCytogenetic AberrationsCytogenetic AbnormalitiesDataDevelopmentDiseaseDisorderDown SyndromeDrugsDysfunctionEnteralEntericEnteric Nervous SystemEsophageal DysmotilityEsophageal RefluxEsophageal motility disordersExhibitsFood AllergyFood HypersensitivityFunctional disorderGERDGI microbiomeGI microbiotaGastro-oesophageal RefluxGastroesophageal RefluxGastroesophageal reflux diseaseGastrointestinal DiseasesGastrointestinal MotilityGastrointestinal microbiotaGeneticHealthHigh PrevalenceHirschsprung DiseaseHospital AdmissionHospitalizationHumanIFN activationImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmunesImmunityImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionIndividualIndividuals with down syndromeInflammationInflammatoryInjuryInterferon ActivationIntermediary MetabolismIntestinal DiseasesIntestinal DisorderIrritable Bowel SyndromeIrritable ColonKnowledgeKynurenineLangdon Down syndromeLaxative PreparationLive BirthMalignant NeoplasmsMalignant TumorMediatingMedicationMetabolicMetabolic ProcessesMetabolismModern ManMolecularMongolismMotilityMotorMucous ColitisNatural regenerationNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNervous System InjuriesNervous System PhysiologyNervous System TraumaNervous System damageNeural CellNeurocyteNeurologicNeurologic DisordersNeurologic functionNeurologicalNeurological DamageNeurological DisordersNeurological InjuryNeurological functionNeurological traumaNeuronsOperative ProceduresOperative Surgical ProceduresPathway interactionsPermeabilityPersonsPharmaceutical PreparationsPhenotypePhysiopathologyPopulationPopulation DecreasesPredispositionPrevalencePrimary Senile Degenerative DementiaProbioticsQOLQuality of lifeRegenerationReportingResearchResectedRisk FactorsRoleSensorySensory DisordersSmall IntestinesSolidSolid NeoplasmSolid TumorSurgicalSurgical InterventionsSurgical ProcedureSusceptibilityTestingTrisomy 21Ulcerated ColitisUlcerative ColitisVariantVariationWorkadulthoodaganglionosisalleviate symptomalter microbiomeameliorating symptomanimal experimentationsautoimmune conditionautoimmune disorderautoimmunity diseasebiologicchromosomal defectchromosome 21 trisomychromosome 21 trisomy syndromechromosome defectcohortcohort research studycohort surveycolon microbiomecolonic microbiomecongenital acromicria syndromedecrease symptomdefined contributiondevelopmentaldigestive tract microbiomedown syndrome individualsdown syndrome patientsdrug/agentdysmotilitydysmotility syndromeeffective therapyeffective treatmententeric microbial communityenteric microbiomeenteric microbiotaexperiencefewer symptomsgastrointestinalgastrointestinal disordergastrointestinal functiongastrointestinal microbial floragastrointestinal microbiomegut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut to brain axisgut-associated microbiomegut-brain axisgut-brain communicationgut-brain interactionsgut-brain relationshipgut-brain signalinginfancyinfantileinflamed coloninflammation markerinflammatory markerinjuriesinjury responseinsightintestinal biomeintestinal floraintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloraintestine diseaseintestine disorderlaxativemalignancymicrobiomemicrobiome adaptationmicrobiome alterationmicrobiome perturbationmorbus Downmotility disordermouse modelmultiomicsmultiple omicsmurine modelneonatal periodneoplasm/cancernervous system functionneural controlneural regulationneurological diseaseneuromodulationneuromodulatoryneuron regenerationneuronalneuronal regenerationneuroregulationneurotraumanew diagnosticsnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynext generation diagnosticsnovelnovel diagnosticsnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpanomicspathophysiologypathwaypatients with down syndromepediatricpelvirectal achalasiapeople with down syndromeprimary degenerative dementiapseudohypertrophic progressive muscular dystrophyreduce symptomsregeneraterelieves symptomsresponse to injurysenile dementia of the Alzheimer typesmall bowelsocial rolespastic colonsurgerysymptom alleviationsymptom reductionsymptom relieftherapeutic targettrisomy 21 syndrome
Description preview
PROJECT SUMMARY.
Down syndrome (DS), caused by Trisomy 21 (T21), occurs in ~1 in 700 live births, making the most commonly
occurring chromosomal abnormality. Individuals with DS experience a unique disease spectrum, whereby they
are protected from some conditions, including solid tumors, and predisposed to others, such as Alzheimer’s
disease and…
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