grant
Defining the neurotoxic and neurodevelopmental health risks of per- and polyfluoroalkyl substances
Organization STATE UNIVERSITY OF NEW YORK AT BUFFALOLocation AMHERST, UNITED STATESPosted 13 Jan 2025Deadline 31 Oct 2029
NIHUS FederalResearch GrantFY20260-11 years oldAD/HDADHDASDAffectAmericanAnionsApopainApoptosisApoptosis PathwayApoptosis-Related Cysteine Protease Caspase 3AssayAttention deficit hyperactivity disorderAutismAutistic DisorderBehaviorBehavioralBindingBinding ProteinsBioassayBioavailabilityBiologic FactorBiological AssayBiological AvailabilityBiological FactorsBloodBlood Reticuloendothelial SystemBody TissuesBrachydanio rerioBrainBrain Nervous SystemCASP-3CASP3CASP3 geneCD36 AntigensCD36 Fatty Acid TransporterCPP-32CPP32CPP32 proteinCPP32BCPP32betaCarrier ProteinsCatalogsCationsCausalityCell BodyCell FunctionCell LineCell PhysiologyCell ProcessCell membraneCellLineCellsCellular FunctionCellular PhysiologyCellular ProcessChemical StructureChemicalsChildChild YouthChildren (0-21)Cognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplexComputer ModelsComputerized ModelsCysteine Protease CPP32Cysteine Protease CPP32 GeneCytoplasmCytoplasmic MembraneDanio rerioDetectionDevelopmentDisturbance in cognitionEarly Infantile AutismEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEncephalonEnd Point AssayEndpoint AssaysEnvironmentEnvironmental ToxinEtiologyExhibitsExperimental ModelsExposure toFatty AcidsFoodFood SupplyGPIV Platelet GlycoproteinGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeneticGoalsHealthHumanImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImpaired cognitionIn VitroIndustrializationInfantile AutismInterventionInvestigationKanner's SyndromeKnowledgeLearningLigand Binding ProteinLigand Binding Protein GeneLinkLytotoxicityMeasurementMeasuresMediatingMitochondriaModelingModern ManMolecularMolecular Dynamics SimulationMolecular InteractionMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMonitorNatureNerve CellsNerve UnitNeural CellNeural DevelopmentNeuritesNeurocyteNeurodevelopmental DisorderNeurological Development DisorderNeuronsNuclearPARP Cleavage ProteasePARP Cleavage Protease GenePFASPathway interactionsPhasePhenotypePhysiologic AvailabilityPlasma MembranePoly-fluoroalkyl substancesPredominantly Hyperactive-Impulsive Type Attention-Deficit DisorderPredominantly Hyperactive-Impulsive Type Hyperactivity DisorderPrevalenceProgrammed Cell DeathProtein BindingProteinsReceptor ProteinReporter GenesResearchRiskRoleSCA-1SCA-1 GeneSREBP Cleavage Activity 1SREBP Cleavage Activity 1 GeneSerum ProteinsSocial BehaviorStimulusStrains Cell LinesSubcellular ProcessSurface Plasmon ResonanceSurvey InstrumentSurveysTestingTherapeuticThrombospondin ReceptorsTissuesToxic Environmental AgentsToxic Environmental SubstancesToxic effectToxicitiesToxinTranscript Expression AnalysesTranscript Expression AnalysisTransgenic OrganismsTransport Protein GeneTransport ProteinsTransporter ProteinWater SupplyWorkYamaYama proteinZebra DanioZebra FishZebrafishanalyze gene expressionautism spectral disorderautism spectrum disorderautistic spectrum disorderbioaccumulationbound proteincaspase-3catalogcausationcell typechemical groupcognitive dysfunctioncognitive losscomputational modelingcomputational modelscomputer based modelscomputer based predictioncomputerized modelingcultured cell linecysteine protease P32cytotoxicitydevelopmentaldisease causationdrinking watereffective interventionefflux pumpenvironmental toxicantexperimentexperimental researchexperimental studyexperimentsexposed human populationfatty acid-transport proteinfetalgene expression analysisgene expression assayhuman exposurein silicoin vivoinhibitorinsightkidslearned behaviorlearning behaviormanufacturemitochondrialmitochondrial dysfunctionmolecular dynamicsmolecular modelingneuralneurodevelopmentneurodevelopment effectneurodevelopmental diseaseneurodevelopmental effectneuron toxicityneuronalneuronal toxicityneurotoxicneurotoxicitypathwayperfluorinated alkyl substancesperfluoro octane sulfonateperfluoro-octane sulfonic acidperfluoroalkyl substancesperfluoroalkylated substancesperfluorooctane sulfonateperfluorooctane sulfonic acidperfluorooctanesulfonateperfluorooctanesulfonic acidpharmacologicplasmalemmapolyfluorinated alkyl substancespolyfluoroalkyl substancespredictive modelingpredictive toxicologypreventpreventingreceptorresponsesocial rolesociobehaviorsociobehavioralstructural determinantsstructural factorssubstance usesubstance usingtoxicity predictiontranscriptional profilingtransgenicuptakeyoungster
Description preview
PROJECT SUMMARY
Per- and polyfluoroalkyl substances (PFAS) are a diverse class of used chemicals that have become ubiquitous
in the environment, contaminating our food and water supplies. A recent survey showed 97% of Americans have
detectable PFAS levels in their blood, resulting from unintentional exposures and bioaccumulation of PFAS.
Exposure…
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